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Isolation and characterization of Puumala hantavirus from Norway: evidence for a distinct phylogenetic sublineage
Ist Teil von
Journal of general virology, 1998-11, Vol.79 (11), p.2603-2614
Ort / Verlag
England: Soc General Microbiol
Erscheinungsjahr
1998
Quelle
MEDLINE
Beschreibungen/Notizen
A Lundkvist, D Wiger, J Horling, KB Sjolander, A Plyusnina, R Mehl, A Vaheri and A Plyusnin
Swedish Institute for Infectious Disease Control, Stockholm. Ake.Lundkvist@smi.ki.se
Puumala (PUU) hantavirus is the aetiological agent of nephropathia
epidemica (NE), a mild form of haemorrhagic fever with renal syndrome,
which occurs in Fennoscandia, central Europe and Russia. In Norway, NE-
like disease has been reported since 1946 and about 50 cases are diagnosed
annually; however, the causative agent has not been characterized. In this
study, a virus originating from bank voles (Clethrionomys glareolus)
trapped near the town of Eidsvoll (Akershus county) was isolated and
passaged in laboratory-bred bank voles. The bank vole strain was identified
as a PUU virus by serological typing and by sequence analysis of the S and
M gene segments. For comparison, complete or partial S sequences were
determined for wild-type PUU strains from five locations in Sweden, two
inhabited by the southern variant of bank vole present in Fennoscandia, and
three by the northern variant. Phylogenetic analysis showed that Norwegian
PUU strains are clustered together with Swedish strains from the first
group forming a well-supported sublineage within the PUU genotype, distinct
from other sublineages from northern Sweden, Finland, Russia and France.
The results are consistent with the view of a complex evolutionary history
of PUU strains in post-glacial Fennoscandia. Analyses of the current
collection of nucleotide sequences suggest that PUU is the most variable
genotype of the known hantaviruses.