Details

Autor(en) / Beteiligte

• Crowley, James J.
• Frederick, Renee M.
• Kook, Minjee
• Wiese, Andrew D.
• Anderberg, Jacey L.
• Adorno, Victor R
• Barrera, Cynthia N
• Best, John R
• Buxbaum, Joseph D
• Cappi, Carolina
• Carneiro, Maria Cecília B
• Munoz, Macarena Churruca
• Daza, Luisa F
• Dreher, Carolina B
• Fazio, Tomas
• Ferrão, Ygor A
• Frederick, Renee M
• Gadad, Bharathi S
• Garrison, Sheldon R
• Goodman, Wayne
• Guzick, Andrew G
• Hovey, Joseph D
• Jimenez Reynolds, Alexandra Z
• Lujambio, Joali Alexandra Juárez
• Lima, Monicke O
• Longhurst, Melanie O
• Lozada Martinez, David A
• Martinez Mallen, Mayra C
• McGuire, Joseph F
• Menezes, Gabriela
• Miguel, Euripedes C
• Minaya, Charlene
• Morales‐Rivero, Alonso
• Moya, Pablo R
• Moyano, María Beatriz
• Naqqash, Zainab
• Núñez Bracho, Ambar A
• Núñez Bracho, Belinda E
• Ortega, Iliana
• Pato, Michele T
• Patrick, Ainsley K
• Mino, Mariel Paz y
• Pereira, Stacey
• Duarte, Tania Pérez
• Ramos, Vanessa R
• Rancourt, Diana
• Sampaio, Aline S
• Schneider, Sophie C
• Stewart, S. Evelyn
• Storch, Shaina B
• Zepeda‐Burgos, Raquel M
• Sampaio, Aline Santos
• Martinho, Ariane Fadel
• Loureiro, Carla Pereira
• Cervone, Flávia
• Menezes, Gabriela Bezerra
• Alves, Gustavo Santiago
• Caminha, Hugo
• Castro Quarantini, Lucas
• Santos Martins, Luiz Felipe Guimarães
• Oliveira Lima, Monicke
• Nagano, Nádia
• Silva, Pedro Pereira Fortes
• Shavitt, Roseli Gedanke
• Santos Ribeiro, Samara
• Silveira Meirelles, Tatiane Veríssimo
• Vasconcellos, Veronica Huhne
• Ferrão, Ygor Arzeno
• Alves, Gilberto S.
• Arellano Espinosa, Alejandro A.
• Ayton, Daphne M.
• Bigdeli, Tim B.
• Burton, Christie L.
• Callahan, Jennifer L.
• Chazelle, Evelyn
• Comer, Jonathan S.
• Crosbie, Jennifer
• Daza, Luisa F.
• Rosa‐Gómez, Anabel
• Dreher, Carolina B.
• Ferrão, Ygor A.
• Fontenelle, Leonardo F.
• Fragoso, Daniele T. H.
• Guttfreund, Daniel G.
• Guzick, Andrew G.
• Hovey, Joseph D.
• Irreño‐Sotomonte, Jonathan
• Janssen‐Aguilar, Reinhard
• Lanzagorta, Nuria
• Balmaceda, Trinidad Olivos
• Placencia, Maritza
• Ramsey, Kesley A.
• Ray, Elise V.
• Sampaio, Aline S.
• Saraiva, Leonardo C.
• Cuevas, Vissente Tapia
• Yanez, Mauricio A.
• Zappa, Luz M.

Titel

Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol

Ist Teil von

• American journal of medical genetics. Part B, Neuropsychiatric genetics, 2024-06, Vol.195 (4), p.e32962-n/a

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long‐sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans‐ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans‐ancestry genomic analyses to accelerate the identification of OCD risk loci, fine‐map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.