Details

Autor(en) / Beteiligte

• Rapin, Alexis
• Rehbinder, Eva Maria
• Macowan, Matthew
• Pattaroni, Céline
• Lødrup Carlsen, Karin C.
• Harris, Nicola L.
• Jonassen, Christine M.
• Landrø, Linn
• Lossius, Astrid H.
• Nordlund, Björn
• Rudi, Knut
• Skjerven, Håvard O.
• Cathrine Staff, Anne
• Söderhäll, Cilla
• Ubags, Niki
• Vettukattil, Riyas
• Marsland, Benjamin J.

Titel

The skin microbiome in the first year of life and its association with atopic dermatitis

Ist Teil von

• Allergy (Copenhagen), 2023-07, Vol.78 (7), p.1949-1963

Ort / Verlag

Denmark: Blackwell Publishing Ltd

Erscheinungsjahr

2023

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Background Early‐life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between the skin microbiome and AD, skin barrier integrity and allergic diseases in the first year of life. We further explored the evolution of the skin microbiome with age and its possible determinants, including delivery mode. Methods Skin microbiome was sampled from the lateral upper arm on the first day of life, and at 3, 6, and 12 months of age. Bacterial communities were assessed by 16S rRNA gene amplicon sequencing in 346 infants from the PreventADALL population‐based birth cohort study, representing 970 samples. Clinical investigations included skin examination and skin barrier function measured as trans‐epidermal water loss (TEWL) at the site and time of microbiome sampling at 3, 6, and 12 months. Parental background information was recorded in electronic questionnaires, and delivery mode (including vaginal delivery (VD), VD in water, elective caesarean section (CS) and emergency CS) was obtained from maternal hospital charts. Results Strong temporal variations in skin bacterial community composition were found in the first year of life, with distinct patterns associated with different ages. Confirming our hypothesis, skin bacterial community composition in the first year of life was associated with skin barrier integrity and later onsets of AD. Delivery mode had a strong impact on the microbiome composition at birth, with each mode leading to distinct patterns of colonization. Other possible determinants of the skin microbiome were identified, including environmental and parental factors as well as breastfeeding. Conclusion Skin microbiome composition during infancy is defined by age, transiently influenced by delivery mode as well as environmental, parental factors and breastfeeding. The microbiome is also associated with skin barrier integrity and the onset of AD. The skin bacterial community composition varies between individuals after birth, then progressively converges during the first year of life. The skin microbiome composition and diversity at birth is associated with later onset of atopic dermatitis with associations found between skin barrier function, dry skin, and bacterial communities. Delivery mode and location are major determinants of the skin microbiome at birth.Abbreviations: NMDS, non‐metric multidimensional scaling; PreventADALL, Preventing Atopic Dermatitis and ALLergies in Children; TEWL, trans‐epidermal water loss