Details

Autor(en) / Beteiligte

• Woych, Jamie
• Ortega Gurrola, Alonso
• Deryckere, Astrid
• Jaeger, Eliza C B
• Gumnit, Elias
• Merello, Gianluca
• Gu, Jiacheng
• Joven Araus, Alberto
• Leigh, Nicholas D
• Yun, Maximina
• Simon, András
• Tosches, Maria Antonietta

Titel

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Ist Teil von

• Science (American Association for the Advancement of Science), 2022-09, Vol.377 (6610), p.eabp9186-eabp9186

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2022

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander . Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR.