Details

Autor(en) / Beteiligte

• Hellsing, Christine
• Örtqvist, Anne K.
• Hagel, Eva
• Mesas‐Burgos, Carmen
• Gustafsson, Ulf O.
• Granström, Anna Löf

Titel

Delivery mode and risk of gastrointestinal disease in the offspring

Ist Teil von

• Acta obstetricia et gynecologica Scandinavica, 2022-10, Vol.101 (10), p.1146-1152

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Introduction The global increase of individuals born by cesarean section with reported levels up to 20% of all deliveries, makes it important to study cesarean section and possible associations that can increase risk of subsequent diseases in children. The aim of the study was to evaluate if cesarean section is associated with increased risk of gastrointestinal disease later in life in a large population‐based cohort. Material and methods In this national population‐based cohort study including all full‐term individuals registered in the Medical Birth Register in Sweden between 1990 and 2000, type of delivery (exposure) was collected from the Medical Birth Register. The study population was followed until 2017 with regards to the outcomes: inflammatory bowel disease (Crohn's disease or ulcerative colitis), appendicitis, cholecystitis, or diverticulitis registered in the Swedish National Patient Register. Cox proportional‐hazards models compared disease‐free survival time between exposed and unexposed. Results The final study population consisted of 1 102 468 individuals of whom 11.6% were delivered by cesarean section and 88.4% were vaginally delivered. In univariate analysis, cesarean section was associated with Crohn's disease (hazard ratio [HR] 1.13, 95% confidence interval [CI] 1.02–1.25), diverticulosis (HR 1.57, 95% CI 1.13–2.18), and cholecystitis (HR 1.16, 95% CI 1.05–1.28). However, the increased risk only remained for Crohn's disease after adjustment for confounders (HR 1.14, 95% CI 1.02–1.27). No associations between delivery mode and appendicitis, ulcerative colitis, cholecystitis, or diverticulosis were found in the multivariate analysis. Conclusions Cesarean section is associated with Crohn's disease later in life, but no other association between delivery mode and gastrointestinal disorders later in life could be found. The global increase of caesarean section makes it important to study the effect of delivery mode for the offspring. This national cohort study concludes that cesarean section is associated with Crohn’s disease in the off‐spring.