UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 11 von 30
Datensatz exportieren als...
BibTeX
The Interaction between HLA‐DRB1 and Smoking in Parkinson's Disease Revisited
Movement disorders, 2022-09, Vol.37 (9), p.1929-1937
Domenighetti, Cloé
Douillard, Venceslas
Sugier, Pierre‐Emmanuel
Sreelatha, Ashwin Ashok Kumar
Schulte, Claudia
Grover, Sandeep
May, Patrick
Bobbili, Dheeraj R.
Radivojkov‐Blagojevic, Milena
Lichtner, Peter
Singleton, Andrew B.
Hernandez, Dena G.
Edsall, Connor
Gourraud, Pierre‐Antoine
Mellick, George D.
Zimprich, Alexander
Pirker, Walter
Rogaeva, Ekaterina
Lang, Anthony E.
Koks, Sulev
Taba, Pille
Lesage, Suzanne
Brice, Alexis
Corvol, Jean‐Christophe
Chartier‐Harlin, Marie‐Christine
Mutez, Eugénie
Brockmann, Kathrin
Deutschländer, Angela B.
Hadjigeorgiou, Georges M.
Dardiotis, Efthimos
Stefanis, Leonidas
Simitsi, Athina Maria
Valente, Enza Maria
Petrucci, Simona
Duga, Stefano
Straniero, Letizia
Zecchinelli, Anna
Pezzoli, Gianni
Brighina, Laura
Ferrarese, Carlo
Annesi, Grazia
Quattrone, Andrea
Gagliardi, Monica
Matsuo, Hirotaka
Nakayama, Akiyoshi
Hattori, Nobutaka
Nishioka, Kenya
Chung, Sun Ju
Kim, Yun Joong
Kolber, Pierre
Warrenburg, Bart P.C.
Bloem, Bastiaan R.
Aasly, Jan
Toft, Mathias
Pihlstrøm, Lasse
Correia Guedes, Leonor
Ferreira, Joaquim J.
Bardien, Soraya
Carr, Jonathan
Tolosa, Eduardo
Ezquerra, Mario
Pastor, Pau
Diez‐Fairen, Monica
Wirdefeldt, Karin
Pedersen, Nancy L.
Ran, Caroline
Belin, Andrea C.
Puschmann, Andreas
Ygland Rödström, Emil
Clarke, Carl E.
Morrison, Karen E.
Tan, Manuela
Krainc, Dimitri
Burbulla, Lena F.
Farrer, Matt J.
Krüger, Rejko
Gasser, Thomas
Sharma, Manu
Vince, Nicolas
Elbaz, Alexis
2022
Details
Autor(en) / Beteiligte
Domenighetti, Cloé
Douillard, Venceslas
Sugier, Pierre‐Emmanuel
Sreelatha, Ashwin Ashok Kumar
Schulte, Claudia
Grover, Sandeep
May, Patrick
Bobbili, Dheeraj R.
Radivojkov‐Blagojevic, Milena
Lichtner, Peter
Singleton, Andrew B.
Hernandez, Dena G.
Edsall, Connor
Gourraud, Pierre‐Antoine
Mellick, George D.
Zimprich, Alexander
Pirker, Walter
Rogaeva, Ekaterina
Lang, Anthony E.
Koks, Sulev
Taba, Pille
Lesage, Suzanne
Brice, Alexis
Corvol, Jean‐Christophe
Chartier‐Harlin, Marie‐Christine
Mutez, Eugénie
Brockmann, Kathrin
Deutschländer, Angela B.
Hadjigeorgiou, Georges M.
Dardiotis, Efthimos
Stefanis, Leonidas
Simitsi, Athina Maria
Valente, Enza Maria
Petrucci, Simona
Duga, Stefano
Straniero, Letizia
Zecchinelli, Anna
Pezzoli, Gianni
Brighina, Laura
Ferrarese, Carlo
Annesi, Grazia
Quattrone, Andrea
Gagliardi, Monica
Matsuo, Hirotaka
Nakayama, Akiyoshi
Hattori, Nobutaka
Nishioka, Kenya
Chung, Sun Ju
Kim, Yun Joong
Kolber, Pierre
Warrenburg, Bart P.C.
Bloem, Bastiaan R.
Aasly, Jan
Toft, Mathias
Pihlstrøm, Lasse
Correia Guedes, Leonor
Ferreira, Joaquim J.
Bardien, Soraya
Carr, Jonathan
Tolosa, Eduardo
Ezquerra, Mario
Pastor, Pau
Diez‐Fairen, Monica
Wirdefeldt, Karin
Pedersen, Nancy L.
Ran, Caroline
Belin, Andrea C.
Puschmann, Andreas
Ygland Rödström, Emil
Clarke, Carl E.
Morrison, Karen E.
Tan, Manuela
Krainc, Dimitri
Burbulla, Lena F.
Farrer, Matt J.
Krüger, Rejko
Gasser, Thomas
Sharma, Manu
Vince, Nicolas
Elbaz, Alexis
Titel
The Interaction between HLA‐DRB1 and Smoking in Parkinson's Disease Revisited
Ist Teil von
Movement disorders, 2022-09, Vol.37 (9), p.1929-1937
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2022
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background Two studies that examined the interaction between HLA‐DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions. Objective To perform a large‐scale independent replication of the HLA‐DRB1 × smoking interaction. Methods We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA‐DRB1. Results At the amino acid level, a valine at position 11 (V11) in HLA‐DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95% confidence interval, 0.59–0.93, PInteraction = 0.028). In silico predictions of the influence of V11 and smoking‐induced modifications of α‐synuclein on binding affinity showed findings consistent with this interaction pattern. Conclusions Despite being one of the most robust findings in PD research, the mechanisms underlying the inverse association between smoking and PD remain unknown. Our findings may help better understand this association. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185, 1531-8257
eISSN: 1531-8257
DOI: 10.1002/mds.29133
Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_150113842
Format
–
Schlagworte
Amino acids
,
Biologi
,
Biological Sciences
,
Drb1 protein
,
Genetic Predisposition to Disease
,
Genetics
,
Genetik
,
gene‐environment interaction
,
HLA
,
HLA-DRB1 Chains - genetics
,
Humans
,
Life Sciences
,
Medicin och hälsovetenskap
,
Movement disorders
,
Natural Sciences
,
Naturvetenskap
,
Neurodegenerative diseases
,
Parkinson Disease - genetics
,
Parkinson's disease
,
Polymorphism, Single Nucleotide - genetics
,
Single-nucleotide polymorphism
,
Smoking
,
Smoking - genetics
,
Synuclein
,
Valine
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX