Details

Autor(en) / Beteiligte

• Knight, W R C
• Zylstra, J
• Wulaningsih, W
• Van Hemelrijck, M
• Landau, D
• Maisey, N
• Gaya, A
• Baker, C R
• Gossage, J A
• Largergren, J
• Davies, A R

Titel

Impact of incremental circumferential resection margin distance on overall survival and recurrence in oesophageal adenocarcinoma

Ist Teil von

• BJS open, 2018-08, Vol.2 (4), p.229-237

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2018

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Previous analyses of the oesophageal circumferential resection margin (CRM) have focused on the prognostic validity of two different definitions of a positive CRM, that of the College of American Pathologists (tumour at margin) and that of the Royal College of Pathologists (tumour within 1 mm). This study aimed to analyse the validity of these definitions and explore the risk of recurrence and survival with incremental tumour distances from the CRM. This cohort study included patients who underwent resection for adenocarcinoma of the oesophagus between 2000 and 2014. Kaplan-Meier and Cox regression analyses were performed to determine the hazard ratio (HR) with 95 per cent confidence intervals for recurrence and mortality in CRM increments: tumour at the cut margin, extending to within 0·1-0·9, 1·0-1·9, 2·0-4·9 mm, and 5·0 mm or more from the margin. A total of 444 patients were included in the study. Kaplan-Meier and unadjusted analyses showed a significant incremental improvement in overall survival (P < 0·001) and recurrence (P for trend < 0·001) rates with increasing distance from the CRM. Tumour distance of 2·0 mm or more remained a significant predictor of survival on multivariable analysis (HR for risk of death 0·66, 95 per cent c.i. 0·44 to 1·00). Multivariable analysis of overall survival demonstrated a significant difference between a positive and negative CRM with the Royal College of Pathologists' definition (HR 1·37, 1·01 to 1·85), but not with the College of American Pathologists' definition (HR 1·22, 0·90 to 1·65). This study demonstrated an incremental improvement in survival and recurrence rates with increasing tumour distance from the CRM.