Details

Autor(en) / Beteiligte

• Salimifard, Sevda
• Karoon Kiani, Fariba
• Sadat Eshaghi, Farzaneh
• Izadi, Sepideh
• Shahdadnejad, Kolsoom
• Masjedi, Ali
• Heydari, Morteza
• Ahmadi, Armin
• Hojjat-Farsangi, Mohammad
• Hassannia, Hadi
• Mohammadi, Hamed
• Boroumand-Noughabi, Samaneh
• Keramati, Mohammad Reza
• Jadidi-Niaragh, Farhad

Titel

Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression

Ist Teil von

• Life Sciences, 2020-11, Vol.260, p.118423-14, Article 118423

Ort / Verlag

New York: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Increased expression of inhibitor of apoptosis (IAP) genes has been associated with progressive cancer and chemoresistance. Accordingly, blockade of IAPs by BV6 has resulted in ameliorative outcomes. Interleukin (IL)-6 is another important mediator involved in the growth and survival of tumor cells. Therefore, we hypothesized that simultaneous inhibition of IAPs and IL-6 could be a new promising anti-tumor treatment strategy. In this study, we generated and characterized hyaluronate-PEG-Chitosan-Lactate (H-PCL) nanoparticles (NPs) to simultaneously deliver IL6-specific siRNA and BV6 to 4T1 (breast cancer) and CT26 (colon cancer) cells, and investigate the anti-tumor properties of this combination therapy both in vitro and in vivo. H-PCL NPs exhibited good physicochemical properties leading to efficient transfection of cancer cells and suppression of target molecules. Moreover, combination therapy synergistically increased apoptosis, as well as decreased cell migration, proliferation, colony formation, and angiogenesis in both 4T1 and CT26 cell lines and suppressed cancer progression in tumor-bearing mice that was associated with enhanced survival time. These findings imply the effectiveness of cancer combination therapy by using H-PCL NPs loaded with anti-IL-6 siRNA and BV6.