Details

Autor(en) / Beteiligte

• Rombach, Ines
• Iftikhar, Marvi
• Jhuti, Gurleen S.
• Gustavsson, Anders
• Lecomte, Pascal
• Belger, Mark
• Handels, Ron
• Castro Sanchez, Amparo Y.
• Kors, Jan
• Hopper, Louise
• Olde Rikkert, Marcel
• Selbæk, Geir
• Stephan, Astrid
• Sikkes, Sietske A. M.
• Woods, Bob
• Gonçalves-Pereira, Manuel
• Zanetti, Orazio
• Ramakers, Inez H. G. B.
• Verhey, Frans R. J.
• Gallacher, John
• Actifcare Consortium
• LeARN Consortium
• Landeiro, Filipa
• Gray, Alastair M.

Titel

Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

Ist Teil von

• Quality of life research, 2021-03, Vol.30 (3), p.867-879

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Purpose The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available. Methods Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error. Results The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset. Conclusions The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.