Details

Autor(en) / Beteiligte

• Brandão, Bruna B.
• Madsen, Søren
• Rabiee, Atefeh
• Oliverio, Matteo
• Ruiz, Gabriel P.
• Ferrucci, Danilo L.
• Branquinho, Jéssica L.
• Razolli, Daniela
• Pinto, Silas
• Nielsen, Thomas S.
• Festuccia, William T.
• Martins, Adriano S.
• Guerra, Beatriz A.
• Knittel, Thiago L.
• Søgaard, Ditte
• Larsen, Steen
• Helge, Jørn W.
• Brandauer, Josef
• Velloso, Lício A.
• Emanuelli, Brice
• Kornfeld, Jan-Wilhelm
• Kahn, Ronald
• Vienberg, Sara G.
• Zierath, Juleen R.
• Treebak, Jonas T.
• Mori, Marcelo A.

Titel

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (38), p.23932-23941

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.