Details

Autor(en) / Beteiligte

• Sekine, Takuya
• Perez-Potti, André
• Rivera-Ballesteros, Olga
• Strålin, Kristoffer
• Gorin, Jean-Baptiste
• Olsson, Annika
• Llewellyn-Lacey, Sian
• Kamal, Habiba
• Bogdanovic, Gordana
• Muschiol, Sandra
• Wullimann, David J.
• Kammann, Tobias
• Emgård, Johanna
• Parrot, Tiphaine
• Folkesson, Elin
• Akber, Mira
• Berglin, Lena
• Bergsten, Helena
• Brighenti, Susanna
• Brownlie, Demi
• Butrym, Marta
• Chambers, Benedict
• Chen, Puran
• Jeannin, Martin Cornillet
• Grip, Jonathan
• Gomez, Angelica Cuapio
• Dillner, Lena
• Lozano, Isabel Diaz
• Dzidic, Majda
• Tullberg, Malin Flodström
• Färnert, Anna
• Glans, Hedvig
• Haroun-Izquierdo, Alvaro
• Henriksson, Elizabeth
• Hertwig, Laura
• Kalsum, Sadaf
• Kokkinou, Efthymia
• Kvedaraite, Egle
• Loreti, Marco
• Lourda, Magalini
• Maleki, Kimia
• Malmberg, Karl-Johan
• Marquardt, Nicole
• Maucourant, Christopher
• Michaelsson, Jakob
• Mjösberg, Jenny
• Moll, Kirsten
• Muva, Jagadees
• Mårtensson, Johan
• Nauclér, Pontus
• Norrby-Teglund, Anna
• Medina, Laura Palma
• Persson, Björn
• Radler, Lena
• Ringqvist, Emma
• Sandberg, John Tyler
• Sohlberg, Ebba
• Soini, Tea
• Svensson, Mattias
• Tynell, Janne
• Varnaite, Renata
• Kries, Andreas Von
• Unge, Christian
• Rooyackers, Olav
• Eriksson, Lars I.
• Henter, Jan-Inge
• Sönnerborg, Anders
• Allander, Tobias
• Albert, Jan
• Nielsen, Morten
• Klingström, Jonas
• Gredmark-Russ, Sara
• Björkström, Niklas K.
• Sandberg, Johan K.
• Price, David A.
• Ljunggren, Hans-Gustaf
• Aleman, Soo
• Buggert, Marcus

Titel

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Ist Teil von

• Cell, 2020-10, Vol.183 (1), p.158-168.e14

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. [Display omitted] •Acute-phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype•Convalescent-phase SARS-CoV-2-specific T cells generate broad responses•Polyfunctional SARS-CoV-2-specific T cells also occur in seronegative individuals Sekine et al. provide a functional and phenotypic map of SARS-CoV-2-specific T cells across the full spectrum of exposure, infection, and COVID-19 severity. They observe that SARS-CoV-2 elicits broadly directed and functionally replete memory T cells that may protect against recurrent episodes of severe COVID-19.