Details

Autor(en) / Beteiligte

• Jaeger, Veronika K
• Tikly, Mohammed
• Xu, Dong
• Siegert, Elise
• Hachulla, Eric
• Airò, Paolo
• Valentini, Gabriele
• Matucci Cerinic, Marco
• Distler, Oliver
• Cozzi, Franco
• Carreira, Patricia
• Allanore, Yannick
• Müller-Ladner, Ulf
• Ananieva, Lidia P
• Balbir-Gurman, Alexandra
• Distler, Jörg H W
• Czirják, Laszlo
• Li, Mengtao
• Henes, Jörg
• Jimenez, Sergio A
• Smith, Vanessa
• Damjanov, Nemanja
• Denton, Christopher P
• DelGaldo, Francesco
• Saketkoo, Lesley Ann
• Walker, Ulrich A

Titel

Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study

Ist Teil von

• Rheumatology, 2020-07, Vol.59 (7), p.1684-1694

Ort / Verlag

Oxford University Press

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Objectives Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. Methods SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. Results The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. Conclusion Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.