Details

Autor(en) / Beteiligte

• Mangeat, Gabriel
• Ouellette, Russell
• Wabartha, Maxime
• De Leener, Benjamin
• Plattén, Michael
• Danylaité Karrenbauer, Virginija
• Warntjes, Marcel
• Stikov, Nikola
• Mainero, Caterina
• Cohen‐Adad, Julien
• Granberg, Tobias

Titel

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis

Ist Teil von

• Journal of neuroimaging, 2020-09, Vol.30 (5), p.674-682

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• ABSTRACT BACKGROUND AND PURPOSE Hereditary diffuse leukoencephalopathy with spheroids (HDLS) and multiple sclerosis (MS) are demyelinating and neurodegenerative disorders that can be hard to distinguish clinically and radiologically. HDLS is a rare disorder compared to MS, which has led to occurrent misdiagnosis of HDLS as MS. That is problematic since their prognosis and treatment differ. Both disorders are investigated by MRI, which could help to identify patients with high probability of having HDLS, which could guide targeted genetic testing to confirm the HDLS diagnosis. METHODS Here, we present a machine learning method based on quantitative MRI that can achieve a robust classification of HDLS versus MS. Four HDLS and 14 age‐matched MS patients underwent a quantitative brain MRI protocol (synthetic MRI) at 3 Tesla (T) (scan time <7 minutes). We also performed a repeatability analysis of the predicting features to assess their generalizability by scanning a healthy control with five scan‐rescans at 3T and 1.5T. RESULTS Our predicting features were measured with an average confidence interval of 1.7% (P = .01), at 3T and 2.3% (P = .01) at 1.5T. The model gave a 100% correct classification of the cross‐validation data when using 5‐11 predicting features. When the maximum measurement noise was inserted in the model, the true positive rate of HDLS was 97.2%, while the true positive rate of MS was 99.6%. CONCLUSIONS This study suggests that computer‐assistance in combination with quantitative MRI may be helpful in aiding the challenging differential diagnosis of HDLS versus MS.