Details

Autor(en) / Beteiligte

• Danielson, Johan
• Karlbom, Urban
• Wester, Tomas
• Graf, Wilhelm

Titel

Injectable bulking treatment of persistent fecal incontinence in adult patients after anorectal malformations

Ist Teil von

• Journal of pediatric surgery, 2020-03, Vol.55 (3), p.397-402

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Injectable bulking therapy has emerged as a treatment for fecal incontinence (FI), however there are no studies including adult patients with anorectal malformations (ARM). This study aimed to evaluate non-animal stabilized hyaluronic acid with dextranomer (NASHA/Dx) for the treatment of adult ARM patients with persistent FI. Seven adults with ARM and incontinence to loose stool at least once weekly and without rectal or mucosal prolapse were treated with anal NASHA/Dx injection. They were evaluated preoperatively, at 6 and 18 months with a bowel function questionnaire and a 2-week bowel diary as well as FIQL and SF-36 quality of life questionnaires. Before treatment, the mean number of incontinence episodes over 2 weeks was 20.7 (median 16, range 8–52). At 6 months, the corresponding figures were 5.3 (median 4, range 0–19, p = 0.018), and at 18 months the figures were 4.3 (median 2, range 1–20, p = 0.018). An improved physical function in SF-36 from 74.3 at baseline to 86.4 at 6 months was noted (p = 0.04). No serious adverse events occurred. NASHA/Dx is a promising treatment option for selected adult patients with persistent FI after ARM. Longer follow up of larger patient series and studies on patients in adolescence is needed. Treatment Study. Level IV.