Details

Autor(en) / Beteiligte

• Pulit, Sara L
• Weng, Lu-Chen
• McArdle, Patrick F
• Trinquart, Ludovic
• Choi, Seung Hoan
• Mitchell, Braxton D
• Rosand, Jonathan
• de Bakker, Paul I W
• Benjamin, Emelia J
• Ellinor, Patrick T
• Kittner, Steven J
• Lubitz, Steven A
• Anderson, Christopher D

Titel

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Ist Teil von

• Neurology. Genetics, 2018-12, Vol.4 (6), p.e293-e293

Ort / Verlag

United States: Wolters Kluwer

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with < 4.4 × 10 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, = 1.45 × 10 ), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, = 0.004), but no other primary stroke subtypes (all > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.