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Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies
Movement disorders, 2020-04, Vol.35 (4), p.595-605
Huber, Maria
Beyer, Leonie
Prix, Catharina
Schönecker, Sonja
Palleis, Carla
Rauchmann, Boris‐Stephan
Morbelli, Silvia
Chincarini, Andrea
Bruffaerts, Rose
Vandenberghe, Rik
Van Laere, Koen
Kramberger, Milica G.
Trost, Maja
Grmek, Marko
Garibotto, Valentina
Nicastro, Nicolas
Frisoni, Giovanni B.
Lemstra, Afina W.
Zande, Jessica
Pilotto, Andrea
Padovani, Alessandro
Garcia‐Ptacek, Sara
Savitcheva, Irina
Ochoa‐Figueroa, Miguel A.
Davidsson, Anette
Camacho, Valle
Peira, Enrico
Arnaldi, Dario
Bauckneht, Matteo
Pardini, Matteo
Sambuceti, Gianmario
Vöglein, Jonathan
Schnabel, Jonas
Unterrainer, Marcus
Perneczky, Robert
Pogarell, Oliver
Buerger, Katharina
Catak, Cihan
Bartenstein, Peter
Cumming, Paul
Ewers, Michael
Danek, Adrian
Levin, Johannes
Aarsland, Dag
Nobili, Flavio
Rominger, Axel
Brendel, Matthias
2020
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Huber, Maria
Beyer, Leonie
Prix, Catharina
Schönecker, Sonja
Palleis, Carla
Rauchmann, Boris‐Stephan
Morbelli, Silvia
Chincarini, Andrea
Bruffaerts, Rose
Vandenberghe, Rik
Van Laere, Koen
Kramberger, Milica G.
Trost, Maja
Grmek, Marko
Garibotto, Valentina
Nicastro, Nicolas
Frisoni, Giovanni B.
Lemstra, Afina W.
Zande, Jessica
Pilotto, Andrea
Padovani, Alessandro
Garcia‐Ptacek, Sara
Savitcheva, Irina
Ochoa‐Figueroa, Miguel A.
Davidsson, Anette
Camacho, Valle
Peira, Enrico
Arnaldi, Dario
Bauckneht, Matteo
Pardini, Matteo
Sambuceti, Gianmario
Vöglein, Jonathan
Schnabel, Jonas
Unterrainer, Marcus
Perneczky, Robert
Pogarell, Oliver
Buerger, Katharina
Catak, Cihan
Bartenstein, Peter
Cumming, Paul
Ewers, Michael
Danek, Adrian
Levin, Johannes
Aarsland, Dag
Nobili, Flavio
Rominger, Axel
Brendel, Matthias
Titel
Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies
Ist Teil von
Movement disorders, 2020-04, Vol.35 (4), p.595-605
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2020
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background Striatal dopamine deficiency and metabolic changes are well‐known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123I‐Ioflupane brain single‐photon emission computed tomography of dopamine transporter and 18F‐fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill‐understood. Objective We used the hitherto largest study cohort of combined imaging from the European consortium to elucidate the role of both biomarkers in the pathophysiological course of dementia with Lewy bodies. Methods We compared striatal dopamine deficiency and glucose metabolism of 84 dementia with Lewy body patients and comparable healthy controls. After normalization of data, we tested their correlation by region‐of‐interest–based and voxel‐based methods, controlled for study center, age, sex, education, and current cognitive impairment. Metabolic connectivity was analyzed by inter‐region coefficients stratified by dopamine deficiency and compared to healthy controls. Results There was an inverse relationship between striatal dopamine availability and relative glucose hypermetabolism, pronounced in the basal ganglia and in limbic regions. With increasing dopamine deficiency, metabolic connectivity showed strong deteriorations in distinct brain regions implicated in disease symptoms, with greatest disruptions in the basal ganglia and limbic system, coincident with the pattern of relative hypermetabolism. Conclusions Relative glucose hypermetabolism and disturbed metabolic connectivity of limbic and basal ganglia circuits are metabolic correlates of dopamine deficiency in dementia with Lewy bodies. Identification of specific metabolic network alterations in patients with early dopamine deficiency may serve as an additional supporting biomarker for timely diagnosis of dementia with Lewy bodies. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185, 1531-8257
eISSN: 1531-8257
DOI: 10.1002/mds.27945
Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_142496058
Format
–
Schlagworte
Basal ganglia
,
Biomarkers
,
Brain
,
Cognitive ability
,
Cohort Studies
,
Computed tomography
,
Dementia
,
Dementia disorders
,
Dopamine
,
dopamine deficiency
,
Dopamine receptors
,
Dopamine transporter
,
Glucose metabolism
,
Humans
,
Lewy Bodies
,
Lewy body dementia
,
Lewy Body Disease - diagnostic imaging
,
Limbic system
,
Medicin och hälsovetenskap
,
metabolic connectivity
,
Metabolic networks
,
Metabolism
,
Movement disorders
,
Neostriatum
,
Neural networks
,
Neuroimaging
,
PET imaging
,
Positron emission tomography
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