Details

Autor(en) / Beteiligte

• Abdo, Hind
• Calvo-Enrique, Laura
• Lopez, Jose Martinez
• Song, Jianren
• Zhang, Ming-Dong
• Usoskin, Dmitry
• El Manira, Abdeljabbar
• Adameyko, Igor
• Hjerling-Leffler, Jens
• Ernfors, Patrik

Titel

Specialized cutaneous Schwann cells initiate pain sensation

Ist Teil von

• Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6454), p.695-699

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2019

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• An essential prerequisite for the survival of an organism is the ability to detect and respond to aversive stimuli. Current belief is that noxious stimuli directly activate nociceptive sensory nerve endings in the skin. We discovered a specialized cutaneous glial cell type with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal and mechanical sensitivity. We demonstrate a direct excitatory functional connection to sensory neurons and provide evidence of a previously unknown organ that has an essential physiological role in sensing noxious stimuli. Thus, these glial cells, which are intimately associated with unmyelinated nociceptive nerves, are inherently mechanosensitive and transmit nociceptive information to the nerve.