British journal of haematology, 2019-05, Vol.185 (4), p.708-712
2019
Details
- Autor(en) / Beteiligte
- Titel
- Expression of GNAZ, encoding the Gαz protein, predicts survival in mantle cell lymphoma
- Ist Teil von
- British journal of haematology, 2019-05, Vol.185 (4), p.708-712
- Ort / Verlag
- England: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Summary Mantle cell lymphoma (MCL), a malignancy of B‐lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real‐time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non‐malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0·014) and lymphocytosis (Mann‐Whitney, P = 0·011). We show that GNAZ translates to Gαz protein – a signalling molecule within the G‐protein coupled receptor network. Our findings suggest that GNAZ/Gαz contribute to the MCL pathobiology.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-1048, 1365-2141eISSN: 1365-2141DOI: 10.1111/bjh.15810Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_140882633
- Format
- –
- Schlagworte
- Biopsy, Cell survival, Down-Regulation - physiology, GTP-Binding Protein alpha Subunits - genetics, GTP-Binding Protein alpha Subunits - metabolism, G‐protein coupled receptors, G‐proteins, Humans, Kaplan-Meier Estimate, Lymphocytes, Lymphocytes B, Lymphocytosis, Lymphoma, Lymphoma, Mantle-Cell - genetics, Lymphoma, Mantle-Cell - metabolism, Lymphoma, Mantle-Cell - mortality, Malignancy, Mantle cell lymphoma, Medical prognosis, Medicin och hälsovetenskap, Polymerase chain reaction, prognosis, Proteins, Real-Time Polymerase Chain Reaction, RNA - metabolism, RNA Interference - physiology