Details

Autor(en) / Beteiligte

• Sim, Xueling
• Feitosa, Mary F
• Zhao, Wei
• Boissel, Mathilde
• Chen, Xu
• Divers, Jasmin
• Evangelou, Evangelos
• Gao, Chuan
• Goel, Anuj
• Hagemeijer, Yanick
• Harris, Sarah E
• He, Meian
• Hsu, Fang-Chi
• Hung, Yi-Jen
• Komulainen, Pirjo
• Luan, Jian'an
• Nolte, Ilja M
• Pietzner, Maik
• Robino, Antonietta
• Sofer, Tamar
• Wang, Tzung-Dau
• Ware, Erin B
• Adeyemo, Adebowale
• Afaq, Saima
• Arking, Dan E
• Aung, Tin
• Campbell, Archie
• Connell, John M
• Duan, Qing
• Eaton, Charles B
• Friedlander, Yechiel
• Ghanbari, Mohsen
• Giulianini, Franco
• Kilpeläinen, Tuomas O
• Krieger, Jose E
• Kritchevsky, Stephen B
• Kuusisto, Johanna
• Langenberg, Claudia
• Launer, Lenore J
• Lehne, Benjamin
• Lewis, Cora E
• Liu, Ching-Ti
• Liu, Jianjun
• Lohman, Kurt K
• Mägi, Reedik
• Mahajan, Anubha
• McKenzie, Colin A
• Milaneschi, Yuri
• Murray, Alison D
• Nalls, Mike A
• Nauck, Matthias
• Palmer, Nicholette D
• Peters, Annette
• Poulter, Neil
• Reiner, Alex P
• Rose, Lynda M
• Rudan, Igor
• Scott, William R
• Sever, Peter
• Shi, Yuan
• Sims, Mario
• Tan, Nicholas Y Q
• Tang, Hua
• Teo, Yik Ying
• Tiemeier, Henning
• Uitterlinden, André G
• Wang, Lan
• Williams, Christine A
• Yao, Jie
• Young, Kristin
• Zhou, Jie
• Cooper, Richard S
• Farrall, Martin
• Freedman, Barry I
• Gieger, Christian
• Juang, Jyh-Ming Jimmy
• Kamatani, Yoichiro
• Kooner, Jaspal S
• Laakso, Markku
• Lehtimäki, Terho
• Rauramaa, Rainer
• Samani, Nilesh J
• Shu, Xiao-Ou
• van der Harst, Pim
• Wang, Ya Xing
• Weir, David R
• Wu, Tangchun
• Bouchard, Claude
• Evans, Michele K
• Kardia, Sharon L R
• Liu, Yongmei
• Fornage, Myriam
• Province, Michael A
• Hayward, Caroline
• Rotter, Jerome I
• Gauderman, W James
• Munroe, Patricia B
• Morrison, Alanna C
• Rao, Dabeeru C
• Rotimi, Charles N

Titel

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Ist Teil von

• Nature genetics, 2019-04, Vol.51 (4), p.636-648

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.