Details

Autor(en) / Beteiligte

• Cox, Maureen A
• Duncan, Gordon S
• Lin, Gloria H Y
• Steinberg, Benjamin E
• Yu, Lisa X
• Brenner, Dirk
• Buckler, Luke N
• Elia, Andrew J
• Wakeham, Andrew C
• Nieman, Brian
• Dominguez-Brauer, Carmen
• Elford, Alisha R
• Gill, Kyle T
• Kubli, Shawn P
• Haight, Jillian
• Berger, Thorsten
• Ohashi, Pamela S
• Tracey, Kevin J
• Olofsson, Peder S
• Mak, Tak W

Titel

Choline acetyltransferase-expressing T cells are required to control chronic viral infection

Ist Teil von

• Science (American Association for the Advancement of Science), 2019-02, Vol.363 (6427), p.639-644

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2019

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4 and CD8 T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. Deletion of within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic LCMV clone 13 infection. Our results reveal a genetic proof of function for ChAT in T cells during viral infection and identify a pathway of T cell migration that sustains antiviral immunity.