Nature genetics, 2019-02, Vol.51 (2), p.245-257
- Karlsson Linnér, Richard
- Biroli, Pietro
- Kong, Edward
- Meddens, S Fleur W
- Wedow, Robbee
- Fontana, Mark Alan
- Lebreton, Maël
- Tino, Stephen P
- Abdellaoui, Abdel
- Hammerschlag, Anke R
- Nivard, Michel G
- Okbay, Aysu
- Rietveld, Cornelius A
- Timshel, Pascal N
- Trzaskowski, Maciej
- Vlaming, Ronald de
- Zünd, Christian L
- Bao, Yanchun
- Buzdugan, Laura
- Caplin, Ann H
- Chen, Chia-Yen
- Eibich, Peter
- Fontanillas, Pierre
- Gonzalez, Juan R
- Joshi, Peter K
- Karhunen, Ville
- Kleinman, Aaron
- Levin, Remy Z
- Lill, Christina M
- Meddens, Gerardus A
- Muntané, Gerard
- Sanchez-Roige, Sandra
- Rooij, Frank J van
- Taskesen, Erdogan
- Wu, Yang
- Zhang, Futao
- Auton, Adam
- Boardman, Jason D
- Clark, David W
- Conlin, Andrew
- Dolan, Conor C
- Fischbacher, Urs
- Groenen, Patrick J F
- Harris, Kathleen Mullan
- Hasler, Gregor
- Hofman, Albert
- Ikram, Mohammad A
- Jain, Sonia
- Karlsson, Robert
- Kessler, Ronald C
- Kooyman, Maarten
- MacKillop, James
- Männikkö, Minna
- Morcillo-Suarez, Carlos
- McQueen, Matthew B
- Schmidt, Klaus M
- Smart, Melissa C
- Sutter, Matthias
- Thurik, A Roy
- Uitterlinden, André G
- White, Jon
- Wit, Harriet de
- Yang, Jian
- Bertram, Lars
- Boomsma, Dorret I
- Esko, Tõnu
- Fehr, Ernst
- Hinds, David A
- Johannesson, Magnus
- Kumari, Meena
- Laibson, David
- Magnusson, Patrik K E
- Meyer, Michelle N
- Navarro, Arcadi
- Palmer, Abraham A
- Pers, Tune H
- Posthuma, Danielle
- Schunk, Daniel
- Stein, Murray B
- Svento, Rauli
- Tiemeier, Henning
- Timmers, Paul R H J
- Turley, Patrick
- Ursano, Robert J
- Wagner, Gert G
- Wilson, James F
- Gratten, Jacob
- Lee, James J
- Cesarini, David
- Benjamin, Daniel J
- Koellinger, Philipp D
- Beauchamp, Jonathan P
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Karlsson Linnér, Richard
- Biroli, Pietro
- Kong, Edward
- Meddens, S Fleur W
- Wedow, Robbee
- Fontana, Mark Alan
- Lebreton, Maël
- Tino, Stephen P
- Abdellaoui, Abdel
- Hammerschlag, Anke R
- Nivard, Michel G
- Okbay, Aysu
- Rietveld, Cornelius A
- Timshel, Pascal N
- Trzaskowski, Maciej
- Vlaming, Ronald de
- Zünd, Christian L
- Bao, Yanchun
- Buzdugan, Laura
- Caplin, Ann H
- Chen, Chia-Yen
- Eibich, Peter
- Fontanillas, Pierre
- Gonzalez, Juan R
- Joshi, Peter K
- Karhunen, Ville
- Kleinman, Aaron
- Levin, Remy Z
- Lill, Christina M
- Meddens, Gerardus A
- Muntané, Gerard
- Sanchez-Roige, Sandra
- Rooij, Frank J van
- Taskesen, Erdogan
- Wu, Yang
- Zhang, Futao
- Auton, Adam
- Boardman, Jason D
- Clark, David W
- Conlin, Andrew
- Dolan, Conor C
- Fischbacher, Urs
- Groenen, Patrick J F
- Harris, Kathleen Mullan
- Hasler, Gregor
- Hofman, Albert
- Ikram, Mohammad A
- Jain, Sonia
- Karlsson, Robert
- Kessler, Ronald C
- Kooyman, Maarten
- MacKillop, James
- Männikkö, Minna
- Morcillo-Suarez, Carlos
- McQueen, Matthew B
- Schmidt, Klaus M
- Smart, Melissa C
- Sutter, Matthias
- Thurik, A Roy
- Uitterlinden, André G
- White, Jon
- Wit, Harriet de
- Yang, Jian
- Bertram, Lars
- Boomsma, Dorret I
- Esko, Tõnu
- Fehr, Ernst
- Hinds, David A
- Johannesson, Magnus
- Kumari, Meena
- Laibson, David
- Magnusson, Patrik K E
- Meyer, Michelle N
- Navarro, Arcadi
- Palmer, Abraham A
- Pers, Tune H
- Posthuma, Danielle
- Schunk, Daniel
- Stein, Murray B
- Svento, Rauli
- Tiemeier, Henning
- Timmers, Paul R H J
- Turley, Patrick
- Ursano, Robert J
- Wagner, Gert G
- Wilson, James F
- Gratten, Jacob
- Lee, James J
- Cesarini, David
- Benjamin, Daniel J
- Koellinger, Philipp D
- Beauchamp, Jonathan P
- Titel
- Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
- Ist Teil von
- Nature genetics, 2019-02, Vol.51 (2), p.245-257
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036, 1546-1718eISSN: 1546-1718DOI: 10.1038/s41588-018-0309-3Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_140196803
- Format
- –
- Schlagworte
- Analysis, Behavior - physiology, Bioinformatics, Brain, Case-Control Studies, Clinical Medicine, Computational biology, Consortia, Domains, Educational attainment, Female, GABA, Gene loci, Genes, Genetic Loci - genetics, Genetic Predisposition to Disease - genetics, Genetics, Genetics, Behavioral - methods, Genome-wide association studies, Genome-Wide Association Study - methods, Genomes, Genomics, Genotype, Genotype & phenotype, Glutamatergic transmission, Human genetics, Humans, Klinisk medicin, Life Sciences, Male, Medical schools, Medicin och hälsovetenskap, Neurotransmission, Obstetrics, Gynecology and Reproductive Medicine, Phenotypes, Polymorphism, Single Nucleotide - genetics, Reproduktionsmedicin och gynekologi, Risk, Risk taking, Schizophrenia, Single nucleotide polymorphisms, Single-nucleotide polymorphism, Smoking, Statistics, Synaptic transmission, γ-Aminobutyric acid