Details

Autor(en) / Beteiligte

• Guo, Qi
• Burgess, Stephen
• Turman, Constance
• Bolla, Manjeet K
• Lush, Michael
• Abraham, Jean
• Aittomäki, Kristiina
• Apicella, Carmel
• Arndt, Volker
• Barrdahl, Myrto
• Benitez, Javier
• Berg, Christine D
• Blomqvist, Carl
• Bojesen, Stig E
• Bonanni, Bernardo
• Brand, Judith S
• Brenner, Hermann
• Broeks, Annegien
• Caldas, Carlos
• Campa, Daniele
• Chang-Claude, Jenny
• Chin, Suet-Feung
• Cox, Angela
• Cross, Simon S
• Cybulski, Cezary
• Czene, Kamila
• Darabi, Hatef
• Devilee, Peter
• Diver, W Ryan
• Dunning, Alison M
• Earl, Helena M
• Ekici, Arif B
• Evans, D Gareth
• Flesch-Janys, Dieter
• Gapstur, Susan M
• Gaudet, Mia M
• Glendon, Gord
• Grip, Mervi
• Haeberle, Lothar
• Haiman, Christopher A
• Hall, Per
• Hamann, Ute
• Hartikainen, Jaana M
• Hiller, Louise
• Holleczek, Bernd
• Hooning, Maartje J
• Hoover, Robert N
• Humphreys, Keith
• Hunter, David J
• Hüsing, Anika
• Jakubowska, Anna
• Jukkola-Vuorinen, Arja
• Kaaks, Rudolf
• Kabisch, Maria
• Kataja, Vesa
• Knight, Julia A
• Kosma, Veli-Matti
• Kristensen, Vessela N
• Lambrechts, Diether
• Le Marchand, Loic
• Li, Jingmei
• Lindblom, Annika
• Lindström, Sara
• Lissowska, Jolanta
• Lubinski, Jan
• Mannermaa, Arto
• Margolin, Sara
• Marme, Federik
• Martens, John W M
• McLean, Catriona
• Menéndez, Primitiva
• Marie Mulligan, Anna
• Nevanlinna, Heli
• Neven, Patrick
• Nielsen, Sune F
• Nordestgaard, Børge G
• Olson, Janet E
• Phillips, Kelly-Anne
• Poole, Christopher J
• Pylkäs, Katri
• Radice, Paolo
• Rudolph, Anja
• Sawyer, Elinor J
• Shah, Mitul
• Smeets, Ann
• Southey, Melissa C
• Tollenaar, Rob A E M
• Tomlinson, Ian
• Tsimiklis, Helen
• Ulmer, Hans-Ulrich
• Vachon, Celine
• van den Ouweland, Ans M W
• Van't Veer, Laura J
• Winqvist, Robert
• Chenevix-Trench, Georgia
• Dörk, Thilo
• Easton, Douglas F
• García-Closas, Montserrat
• Kraft, Peter
• Zheng, Wei

Titel

Body mass index and breast cancer survival: a Mendelian randomization analysis

Ist Teil von

• International journal of epidemiology, 2017-12, Vol.46 (6), p.1814-1822

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2017

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13, P = 0.95). Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.