Details

Autor(en) / Beteiligte

• Sorce, Silvia
• Stocker, Roland
• Seredenina, Tamara
• Holmdahl, Rikard
• Aguzzi, Adriano
• Chio, Adriano
• Depaulis, Antoine
• Heitz, Freddy
• Olofsson, Peter
• Olsson, Tomas
• Duveau, Venceslas
• Sanoudou, Despina
• Skosgater, Sara
• Vlahou, Antonia
• Wasquel, Dominique
• Krause, Karl-Heinz
• Jaquet, Vincent

Titel

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

Ist Teil von

• Free radical biology & medicine, 2017-11, Vol.112, p.387-396

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Neurodegenerative disease are frequently characterized by microglia activation and/or leukocyte infiltration in the parenchyma of the central nervous system and at the molecular level by increased oxidative modifications of proteins, lipids and nucleic acids. NADPH oxidases (NOX) emerged as a novel promising class of pharmacological targets for the treatment of neurodegeneration due to their role in oxidant generation and presumably in regulating microglia activation. The unique function of NOX is the generation of superoxide anion (O2•–) and hydrogen peroxide (H2O2). However in the context of neuroinflammation, they present paradoxical features since O2•–/H2O2 generated by NOX and/or secondary reactive oxygen species (ROS) derived from O2•–/H2O2 can either lead to neuronal oxidative damage or resolution of inflammation. The role of NOX enzymes has been investigated in many models of neurodegenerative diseases by using either genetic or pharmacological approaches. In the present review we provide a critical assessment of recent findings related to the role of NOX in the CNS as well as how the field has advanced over the last 5 years. In particular, we focus on the data derived from the work of a consortium (Neurinox) funded by the European Commission's Programme 7 (FP7). We discuss the evidence gathered from animal models and human samples linking NOX expression/activity with neuroinflammation in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Creutzfeldt–Jakob disease as well as autoimmune demyelinating diseases like multiple sclerosis (MS) and chronic inflammatory demyelinating polyneuropathy (CIDP). We address the possibility to use measurement of the activity of the NOX2 isoform in blood samples as biomarker of disease severity and treatment efficacy in neurodegenerative disease. Finally we clarify key controversial aspects in the field of NOX, such as NOX cellular expression in the brain, measurement of NOX activity, impact of genetic deletion of NOX in animal models of neurodegeneration and specificity of NOX inhibitors. Generation of oxidants by NOX follows a Gaussian distribution in the general population, where both extremes of the bell-shaped curve are considered to promote neurodegenerative diseases. Too little NOX2 activity promotes autoimmune neurodegeneration while too much NOX2 activity promotes microglia-dependent neurodegenerative mechanisms. The arrows represent potential therapeutic approaches to reach normal redox function in the CNS. [Display omitted]