Details

Autor(en) / Beteiligte

• Peng, Changgeng
• Li, Lili
• Zhang, Ming-Dong
• Gonzales, Carolina Bengtsson
• Parisien, Marc
• Belfer, Inna
• Usoskin, Dmitry
• Abdo, Hind
• Furlan, Alessandro
• Häring, Martin
• Lallemend, Francois
• Harkany, Tibor
• Diatchenko, Luda
• Hökfelt, Tomas
• Hjerling-Leffler, Jens
• Ernfors, Patrik

Titel

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes

Ist Teil von

• Science (American Association for the Advancement of Science), 2017-06, Vol.356 (6343), p.1168-1171

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2017

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Nociception is protective and prevents tissue damage but can also facilitate chronic pain. Whether a general principle governs these two types of pain is unknown. Here, we show that both basal mechanical and neuropathic pain are controlled by the microRNA-183 (miR-183) cluster in mice. This single cluster controls more than 80% of neuropathic pain–regulated genes and scales basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gated calcium channel subunits α2δ-1 and α2δ-2. Basal sensitivity is controlled in nociceptors, and allodynia involves TrkB⁺ light-touch mechanoreceptors. These light-touch–sensitive neurons, which normally do not elicit pain, produce pain during neuropathy that is reversed by gabapentin. Thus, a single microRNA cluster continuously scales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain transduction in a specific, light-touch–sensitive neuronal type recruited during mechanical allodynia.