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rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk
Scientific reports, 2016-11, Vol.6 (1), p.36874, Article 36874
2016

Details

Autor(en) / Beteiligte
Titel
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk
Ist Teil von
  • Scientific reports, 2016-11, Vol.6 (1), p.36874, Article 36874
Ort / Verlag
England: Nature Publishing Group
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
Beschreibungen/Notizen
  • NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r  > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.
Sprache
Englisch
Identifikatoren
ISSN: 2045-2322
eISSN: 2045-2322
DOI: 10.1038/srep36874
Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_134604315
Format
–
Schlagworte
3' Untranslated Regions, Age, Alleles, Binding Sites, BRCA1 protein, BRCA1 Protein - genetics, BRCA2 Protein - genetics, Breast cancer, Breast feeding, Breast Neoplasms - genetics, Breast Neoplasms - pathology, Cell Cycle Proteins - genetics, Colorectal carcinoma, Female, Gene polymorphism, Genetic Predisposition to Disease, Genotype, Health risk assessment, Hormone replacement therapy, Humans, Lung cancer, Medicin och hälsovetenskap, Menarche, Menopause, MicroRNAs, MicroRNAs - metabolism, miRNA, Nuclear Proteins - genetics, Odds Ratio, Polymerase chain reaction, Polymorphism, Single Nucleotide, Restriction fragment length polymorphism, Risk Factors

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