Details

Autor(en) / Beteiligte

• Costanzo, Michael
• VanderSluis, Benjamin
• Koch, Elizabeth N.
• Baryshnikova, Anastasia
• Pons, Carles
• Tan, Guihong
• Wang, Wen
• Usaj, Matej
• Hanchard, Julia
• Lee, Susan D.
• Pelechano, Vicent
• Styles, Erin B.
• Billmann, Maximilian
• van Leeuwen, Jolanda
• van Dyk, Nydia
• Lin, Zhen-Yuan
• Kuzmin, Elena
• Nelson, Justin
• Piotrowski, Jeff S.
• Srikumar, Tharan
• Bahr, Sondra
• Chen, Yiqun
• Deshpande, Raamesh
• Kurat, Christoph F.
• Li, Sheena C.
• Li, Zhijian
• Usaj, Mojca Mattiazzi
• Okada, Hiroki
• Pascoe, Natasha
• San Luis, Bryan-Joseph
• Sharifpoor, Sara
• Shuteriqi, Emira
• Simpkins, Scott W.
• Snider, Jamie
• Suresh, Harsha Garadi
• Tan, Yizhao
• Zhu, Hongwei
• Malod-Dognin, Noel
• Janjic, Vuk
• Przulj, Natasa
• Troyanskaya, Olga G.
• Stagljar, Igor
• Xia, Tian
• Ohya, Yoshikazu
• Gingras, Anne-Claude
• Raught, Brian
• Boutros, Michael
• Steinmetz, Lars M.
• Moore, Claire L.
• Rosebrock, Adam P.
• Caudy, Amy A.
• Myers, Chad L.
• Andrews, Brenda
• Boone, Charles

Titel

A global genetic interaction network maps a wiring diagram of cellular function

Ist Teil von

• Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6306), p.1381-1381

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments. Negative interactions connected functionally related genes, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often mapped general regulatory connections among gene pairs, rather than shared functionality. The global network illustrates how coherent sets of genetic interactions connect protein complex and pathway modules to map a functional wiring diagram of the cell.