Details

Autor(en) / Beteiligte

• Nettleton, Jennifer A
• Follis, Jack L
• Ngwa, Julius S
• Smith, Caren E
• Ahmad, Shafqat
• Tanaka, Toshiko
• Wojczynski, Mary K
• Voortman, Trudy
• Lemaitre, Rozenn N
• Kristiansson, Kati
• Nuotio, Marja-Liisa
• Houston, Denise K
• Perälä, Mia-Maria
• Qi, Qibin
• Sonestedt, Emily
• Manichaikul, Ani
• Kanoni, Stavroula
• Ganna, Andrea
• Mikkilä, Vera
• North, Kari E
• Siscovick, David S
• Harald, Kennet
• Mckeown, Nicola M
• Johansson, Ingegerd
• Rissanen, Harri
• Liu, Yongmei
• Lahti, Jari
• Hu, Frank B
• Bandinelli, Stefania
• Rukh, Gull
• Rich, Stephen
• Booij, Lisanne
• Dmitriou, Maria
• Ax, Erika
• Raitakari, Olli
• Mukamal, Kenneth
• Männistö, Satu
• Hallmans, Göran
• Jula, Antti
• Ericson, Ulrika
• Jacobs, Jr, David R
• Van Rooij, Frank J A
• Deloukas, Panos
• Sjögren, Per
• Kähönen, Mika
• Djousse, Luc
• Perola, Markus
• Barroso, Inês
• Hofman, Albert
• Stirrups, Kathleen
• Viikari, Jorma
• Uitterlinden, André G
• Kalafati, Ioanna P
• Franco, Oscar H
• Mozaffarian, Dariush
• Salomaa, Veikko
• Borecki, Ingrid B
• Knekt, Paul
• Kritchevsky, Stephen B
• Eriksson, Johan G
• Dedoussis, George V
• Qi, Lu
• Ferrucci, Luigi
• Orho-Melander, Marju
• Zillikens, M Carola
• Ingelsson, Erik
• Lehtimäki, Terho
• Renström, Frida
• Cupples, L Adrienne
• Loos, Ruth J F
• Franks, Paul W

Titel

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

Ist Teil von

• Human molecular genetics, 2015-08, Vol.24 (16), p.4728-4738

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. Totally, 32 body mass index (BMI)- and 14 waist-hip ratio (WHR)-associated single nucleotide polymorphisms were genotyped, and genetic risk scores (GRS) were calculated in 18 cohorts of European ancestry (n = 68 317). Diet score was calculated based on self-reported intakes of whole grains, fish, fruits, vegetables, nuts/seeds (favorable) and red/processed meats, sweets, sugar-sweetened beverages and fried potatoes (unfavorable). Multivariable adjusted, linear regression within each cohort followed by inverse variance-weighted, fixed-effects meta-analysis was used to characterize: (a) associations of each GRS with BMI and BMI-adjusted WHR and (b) diet score modification of genetic associations with BMI and BMI-adjusted WHR. Nominally significant interactions (P = 0.006-0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjusted WHR or BMI outcomes. Although the magnitudes of these select interactions were small, our data indicated that associations between genetic predisposition and obesity traits were stronger with a healthier diet. Our findings generate interesting hypotheses; however, experimental and functional studies are needed to determine their clinical relevance.