Details

Autor(en) / Beteiligte

• Poortmans, Philip M
• Collette, Sandra
• Kirkove, Carine
• Van Limbergen, Erik
• Budach, Volker
• Struikmans, Henk
• Collette, Laurence
• Fourquet, Alain
• Maingon, Philippe
• Valli, Mariacarla
• De Winter, Karin
• Marnitz, Simone
• Barillot, Isabelle
• Scandolaro, Luciano
• Vonk, Ernest
• Rodenhuis, Carla
• Marsiglia, Hugo
• Weidner, Nicola
• van Tienhoven, Geertjan
• Glanzmann, Christoph
• Kuten, Abraham
• Arriagada, Rodrigo
• Bartelink, Harry
• Van den Bogaert, Walter

Titel

Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer

Ist Teil von

• The New England journal of medicine, 2015-07, Vol.373 (4), p.317-327

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, irradiation of the internal mammary and medial supraclavicular nodes plus whole breast or thoracic-wall radiation therapy in women with localized breast cancer was linked to increased disease-free survival but only a marginal gain in overall survival. The first filter stations for the lymphatic drainage of the breast are the axillary and internal mammary lymph nodes. 1 Surgical studies have shown that the incidence of metastatic involvement of the internal mammary nodes varies between 4% and 9% in patients with axillary node–negative breast cancer and between 16% and 65% in patients with axillary node–positive breast cancer. 2 – 4 As a consequence, surgical dissection of the internal mammary nodes was attempted but abandoned in the 1970s, since no improvement in survival was observed. 4 , 5 Elective irradiation of the regional nodes remained widely used until the late 1980s, when it became . . .