Details

Autor(en) / Beteiligte

• Surakka, Ida
• Horikoshi, Momoko
• Mägi, Reedik
• Sarin, Antti-Pekka
• Mahajan, Anubha
• Lagou, Vasiliki
• Marullo, Letizia
• Ferreira, Teresa
• Miraglio, Benjamin
• Timonen, Sanna
• Kettunen, Johannes
• Pirinen, Matti
• Karjalainen, Juha
• Thorleifsson, Gudmar
• Hägg, Sara
• Hottenga, Jouke-Jan
• Isaacs, Aaron
• Ladenvall, Claes
• Beekman, Marian
• Esko, Tõnu
• Ried, Janina S
• Nelson, Christopher P
• Willenborg, Christina
• Gustafsson, Stefan
• Westra, Harm-Jan
• Blades, Matthew
• de Craen, Anton J M
• de Geus, Eco J
• Deelen, Joris
• Grallert, Harald
• Hamsten, Anders
• Havulinna, Aki S
• Hengstenberg, Christian
• Houwing-Duistermaat, Jeanine J
• Hyppönen, Elina
• Karssen, Lennart C
• Lehtimäki, Terho
• Lyssenko, Valeriya
• Magnusson, Patrik K E
• Mihailov, Evelin
• Müller-Nurasyid, Martina
• Mpindi, John-Patrick
• Pedersen, Nancy L
• Penninx, Brenda W J H
• Perola, Markus
• Pers, Tune H
• Peters, Annette
• Rung, Johan
• Smit, Johannes H
• Steinthorsdottir, Valgerdur
• Tobin, Martin D
• Tsernikova, Natalia
• van Leeuwen, Elisabeth M
• Viikari, Jorma S
• Willems, Sara M
• Willemsen, Gonneke
• Schunkert, Heribert
• Erdmann, Jeanette
• Samani, Nilesh J
• Kaprio, Jaakko
• Lind, Lars
• Gieger, Christian
• Metspalu, Andres
• Slagboom, P Eline
• Groop, Leif
• van Duijn, Cornelia M
• Eriksson, Johan G
• Jula, Antti
• Salomaa, Veikko
• Boomsma, Dorret I
• Power, Christine
• Raitakari, Olli T
• Ingelsson, Erik
• Järvelin, Marjo-Riitta
• Thorsteinsdottir, Unnur
• Franke, Lude
• Ikonen, Elina
• Kallioniemi, Olli
• Pietiäinen, Vilja
• Lindgren, Cecilia M
• Stefansson, Kari
• Palotie, Aarno
• McCarthy, Mark I
• Morris, Andrew P
• Prokopenko, Inga
• Ripatti, Samuli

Titel

The impact of low-frequency and rare variants on lipid levels

Ist Teil von

• Nature genetics, 2015-06, Vol.47 (6), p.589-597

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, including 79 previously identified loci with new lead SNPs and 10 new loci, 15 loci with a low-frequency lead SNP and 10 loci with a missense lead SNP, and 2 loci with an accumulation of rare variants. In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutations with predicted damaging function (CD300LG and TM6SF2) explained the locus associations. The low-frequency variants increased the proportion of variance explained, particularly for low-density lipoprotein cholesterol and total cholesterol. Altogether, our results highlight the impact of low-frequency variants in complex traits and show that imputation offers a cost-effective alternative to resequencing.