Details

Autor(en) / Beteiligte

• Kote-Jarai, Zsofia
• Schumacher, Fredrick
• Han, Ying
• Benlloch, Sara
• Wang, Zhaoming
• Leongamornlert, Daniel
• Lindstrom, Sara
• Jugurnauth-Little, Sara
• Tymrakiewicz, Malgorzata
• Rand, Kristin
• Wan, Peggy
• Sheng, Xin
• Pooler, Loreall C
• Park, Karen
• Tyrer, Jonathan
• Kolonel, Laurence N
• Le Marchand, Loic
• Hoover, Robert N
• Yeager, Merideth
• Chung, Charles C
• Goh, Chee
• Ahmed, Mahbubl
• Govindasami, Koveela
• Tammela, Teuvo L J
• Wahlfors, Tiina
• Leinonen, Katri A
• Xu, Jianfeng
• Donovan, Jenny
• Travis, Ruth C
• Key, Tim J
• Siddiq, Afshan
• Canzian, Federico
• Khaw, Kay-Tee
• Takahashi, Atsushi
• Kubo, Michiaki
• Pharoah, Paul
• Weischer, Maren
• Nielsen, Sune F
• Klarskov, Peter
• Røder, Martin Andreas
• Iversen, Peter
• McDonnell, Shannon K
• Stanford, Janet L
• Kolb, Suzanne
• Coll, Antonio Hurtado
• Herkommer, Kathleen
• Strom, Sara S
• Pettaway, Curtis
• Tettey, Yao
• Biritwum, Richard B
• Tay, Evelyn
• Chokkalingam, Anand P
• Cybulski, Cezary
• Kluźniak, Wojciech
• Isaacs, William B
• Brenner, Hermann
• Dieffenbach, Aida Karina
• Stegmaier, Christa
• Giovannucci, Edward L
• Ma, Jing
• Stampfer, Meir
• Penney, Kathryn L
• John, Esther M
• Ingles, Sue A
• Murphy, Adam B
• Pandha, Hardev
• Michael, Agnieszka
• Kierzek, Andrzej M
• Signorello, Lisa B
• Zheng, Wei
• Weinstein, Stephanie
• Carpten, John
• Wu, Suh-Yuh
• Hennis, Anselm
• Kibel, Adam S
• Rybicki, Benjamin A
• Neslund-Dudas, Christine
• Chu, Lisa
• Clements, Judith
• Spurdle, Amanda
• Teixeira, Manuel R
• Slavov, Chavdar
• Kaneva, Radka
• Mitev, Vanio
• Witte, John S
• Casey, Graham
• Gillanders, Elizabeth M
• Seminara, Daniella
• Riboli, Elio
• Freedman, Matthew L
• Muir, Kenneth
• Gronberg, Henrik
• Southey, Melissa
• Giles, Graham G
• Severi, Gianluca
• Cook, Michael B
• Wiklund, Fredrik
• Easton, Douglas F
• Eeles, Rosalind A
• Haiman, Christopher A

Titel

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Ist Teil von

• Nature genetics, 2014-10, Vol.46 (10), p.1103-1109

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.