Details

Autor(en) / Beteiligte

• Lagerqvist, Bo
• Fröbert, Ole
• Olivecrona, Göran K
• Gudnason, Thórarinn
• Maeng, Michael
• Alström, Patrik
• Andersson, Jonas
• Calais, Fredrik
• Carlsson, Jörg
• Collste, Olov
• Götberg, Matthias
• Hårdhammar, Peter
• Ioanes, Dan
• Kallryd, Anders
• Linder, Rickard
• Lundin, Anders
• Odenstedt, Jacob
• Omerovic, Elmir
• Puskar, Verner
• Tödt, Tim
• Zelleroth, Eva
• Östlund, Ollie
• James, Stefan K

Titel

Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction

Ist Teil von

• The New England journal of medicine, 2014-09, Vol.371 (12), p.1111-1120

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In a randomized trial, over 7000 patients with ST-segment elevation MI were assigned to undergo thrombus aspiration followed by percutaneous coronary intervention or PCI alone. At 1 year, there was no significant between-group difference in the rate of death from any cause. Acute ST-segment elevation myocardial infarction (STEMI) is often caused by intracoronary thrombus formation with blockage of antegrade coronary flow leading to myocardial ischemia and cell death. 1 Thrombus burden, reduced coronary flow, and reduced myocardial perfusion are important predictors of a poor clinical outcome, including recurrence of myocardial infarction, stent thrombosis, and death. 2 Prompt initiation of antithrombotic therapy in combination with percutaneous coronary intervention (PCI) is the preferred approach to optimize myocardial perfusion and clinical outcomes. 3 Coronary-artery thrombus aspiration before PCI reduces the thrombus burden and improves ST-segment resolution and coronary flow. 4 , 5 To our knowledge, however, no adequately powered randomized . . .