Details

Autor(en) / Beteiligte

• Fedirko, Veronika
• Romieu, Isabelle
• Aleksandrova, Krasimira
• Pischon, Tobias
• Trichopoulos, Dimitrios
• Peeters, Petra H.
• Romaguera‐Bosch, Dora
• Bueno‐de‐Mesquita, H. B(as)
• Dahm, Christina C.
• Overvad, Kim
• Chirlaque, Maria‐Dolores
• Johansen, Christoffer
• Bidstrup, Pernille E.
• Dalton, Susanne O.
• Gunter, Marc J.
• Wark, Petra A.
• Norat, Teresa
• Halkjær, Jytte
• Tjønneland, Anne
• Dik, Vincent K.
• Siersema, Peter D.
• Boutron‐Ruault, Marie‐Christine
• Dossus, Laure
• Bastide, Nadia
• Kühn, Tilman
• Kaaks, Rudolf
• Boeing, Heiner
• Trichopoulou, Antonia
• Klinaki, Eleni
• Katsoulis, Michalis
• Pala, Valeria
• Panico, Salvatore
• Tumino, Rosario
• Palli, Domenico
• Vineis, Paolo
• Weiderpass, Elisabete
• Skeie, Guri
• González, Carlos A.
• Sánchez, María‐José
• Barricarte, Aurelio
• Amiano, Pilar
• Quiros, J. Ramon
• Manjer, Jonas
• Jirström, Karin
• Ljuslinder, Ingrid
• Palmqvist, Richard
• Khaw, Kay‐Tee
• Wareham, Nick
• Bradbury, Kathryn E.
• Stepien, Magdalena
• Duarte‐Salles, Talita
• Riboli, Elio
• Jenab, Mazda

Titel

Pre‐diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

Ist Teil von

• International journal of cancer, 2014-10, Vol.135 (8), p.1949-1960

Ort / Verlag

Hoboken, NJ: Wiley-Blackwell

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre‐diagnostic anthropometric characteristics and CRC‐specific and all‐cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow‐up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre‐diagnostic BMI ≥30 kg/m2 was associated with a high risk for CRC‐specific (HR = 1.26, 95% CI = 1.04–1.52) and all‐cause (HR = 1.32, 95% CI = 1.12–1.56) death relative to BMI <25 kg/m2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC‐specific (HR = 1.10, 95% CI = 1.02–1.19) and all‐cause death (HR = 1.12, 95% CI = 1.05–1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC‐specific (HR = 1.09, 95% CI = 1.02–1.16) and all‐cause death (HR = 1.11, 95% CI = 1.05–1.18). Similar associations were observed for waist‐to‐hip and waist‐to‐height ratios. Height was not associated with CRC‐specific or all‐cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre‐diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis. What's new? Both general and abdominal obesity are associated with an increased risk of developing colorectal cancer (CRC), but whether one or both types of obesity affect survival in CRC has been unclear. In this study, the authors found that, indeed, each type of fat was independently associated with an increased risk for CRC‐specific and all‐cause death. However, CRC patients with both types of obesity had the highest risk of death. These results underline the importance of maintaining a healthy weight throughout life.