Details

Autor(en) / Beteiligte

• Lukkarinen, Heikki, MD
• Söderlund-Venermo, Maria, PhD
• Vuorinen, Tytti, MD
• Allander, Tobias, MD
• Hedman, Klaus, MD
• Simell, Olli, MD
• Ruuskanen, Olli, MD
• Jartti, Tuomas, MD

Titel

Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children

Ist Teil von

• Journal of allergy and clinical immunology, 2014-01, Vol.133 (1), p.256-258.e4

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective of this study was to compare the systemic TH1-type, TH2-type, IL-10, and proinflammatory cytokine profiles in young children with sole RV- or sole HBoV1-associated wheezing. [...]we wanted to investigate whether codetection of RV and HBoV1 would be associated with a different cytokine response than would detection of either virus alone. All acute HBoV1 infections were serologically confirmed.6 Serum taken at study entry was analyzed for the following cytokines by using the Human Cytokine LINCO plex Kit (Millipore Corporation, Billerica, Mass; sensitivities for each cytokine are shown in Table E1 in this article's Online Repository at www.jacionline.org): GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, and TNF-[alpha].7 Children were followed up for 7 years, and the time to recurrent wheezing was assessed as previously defined.2 The normality of data distribution was tested by using the Kolmogorov-Smirnov test. Because of the skewness of the data, cytokine levels were log10 transformed.