Vaccine, 2012-03, Vol.30 (15), p.2523-2534
2012
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- Autor(en) / Beteiligte
- Titel
- Immunization with apoptotic pseudovirus transduced cells induces both cellular and humoral responses: A proof of concept study in macaques
- Ist Teil von
- Vaccine, 2012-03, Vol.30 (15), p.2523-2534
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► We measure responses after immunization of apoptotic T-cells carrying defective SIV. ► Local transient skin reactions appear at injection site. ► SIV Gag-specific IFN-γ and IL-2 responses are detected. ► SIV Gag-specific antibody response with neutralizing activity are induced.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410X, 1873-2518eISSN: 1873-2518DOI: 10.1016/j.vaccine.2012.01.082Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_124414868
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Antibodies, Antibodies, Neutralizing - immunology, Antibodies, Viral - immunology, Antigen presentation, Apoptosis, Apoptosis - immunology, Apoptotic cell, B-cells, CD4 antigen, CD4 Antigens - metabolism, CD4-positive T-lymphocytes, Cell Line, cell-mediated immunity, Cytokines, Defective Viruses - genetics, Defective Viruses - immunology, Dendritic cells, digestive system, Digestive tract, Epitopes - immunology, Experiments, gamma -Interferon, Gene Products, gag - immunology, genes, Human immunodeficiency virus, Humans, humoral immunity, Immune response, Immune response (humoral), Immune system, Immunity, Cellular, Immunity, Humoral, Immunization, Immunogenicity, Infections, interferon-gamma, Interferon-gamma - immunology, Interleukin 2, intravenous injection, Ki-67 Antigen - metabolism, Lymphocytes, Lymphocytes T, Macaca mulatta, Macaca mulatta - immunology, Medicin och hälsovetenskap, mice, neutralization, Peripheral blood, Preservation, Primates, Pseudovirus, Replication, SAIDS Vaccines - genetics, SAIDS Vaccines - immunology, Simian Acquired Immunodeficiency Syndrome - immunology, Simian Acquired Immunodeficiency Syndrome - prevention & control, Simian Acquired Immunodeficiency Syndrome - virology, Simian immunodeficiency virus, Simian Immunodeficiency Virus - genetics, Simian Immunodeficiency Virus - immunology, SIV, Studies, T-cells, T-Lymphocytes - immunology, T-Lymphocytes - metabolism, T-Lymphocytes - virology, Transduction, Genetic, Vaccination, vaccines, viral antigens, Viral Load