Nature genetics, 2011-09, Vol.43 (9), p.825-827
- Houlston, Richard S
- Dobbins, Sara E
- Broderick, Peter
- Melin, Beatrice
- Feychting, Maria
- Johansen, Christoffer
- Andersson, Ulrika
- Brännström, Thomas
- Schramm, Johannes
- Olver, Bianca
- Lloyd, Amy
- Ma, Yussanne P
- Hosking, Fay J
- Lönn, Stefan
- Ahlbom, Anders
- Henriksson, Roger
- Schoemaker, Minouk J
- Hepworth, Sarah J
- Hoffmann, Per
- Mühleisen, Thomas W
- Nöthen, Markus M
- Moebus, Susanne
- Eisele, Lewin
- Kosteljanetz, Michael
- Muir, Kenneth
- Swerdlow, Anthony
- Simon, Matthias
2011
Details
- Autor(en) / Beteiligte
- Houlston, Richard S
- Dobbins, Sara E
- Broderick, Peter
- Melin, Beatrice
- Feychting, Maria
- Johansen, Christoffer
- Andersson, Ulrika
- Brännström, Thomas
- Schramm, Johannes
- Olver, Bianca
- Lloyd, Amy
- Ma, Yussanne P
- Hosking, Fay J
- Lönn, Stefan
- Ahlbom, Anders
- Henriksson, Roger
- Schoemaker, Minouk J
- Hepworth, Sarah J
- Hoffmann, Per
- Mühleisen, Thomas W
- Nöthen, Markus M
- Moebus, Susanne
- Eisele, Lewin
- Kosteljanetz, Michael
- Muir, Kenneth
- Swerdlow, Anthony
- Simon, Matthias
- Titel
- Common variation at 10p12.31 near MLLT10 influences meningioma risk
- Ist Teil von
- Nature genetics, 2011-09, Vol.43 (9), p.825-827
- Ort / Verlag
- New York, NY: Nature Publishing Group
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, Pcombined = 1.88 × 10−14). This finding advances our understanding of the genetic basis of meningioma development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036, 1546-1718eISSN: 1546-1718DOI: 10.1038/ng.879Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_123171875
- Format
- –
- Schlagworte
- Biological and medical sciences, Brain, Chromosomes, Human, Pair 10 - genetics, Data collection, Fundamental and applied biological sciences. Psychology, Genetic aspects, Genetic Loci, Genetic Predisposition to Disease, Genetic variation, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Genomes, Genotype & phenotype, Humans, Male, Medical sciences, Medicin och hälsovetenskap, Meningeal Neoplasms - epidemiology, Meningeal Neoplasms - genetics, Meningioma, Meningioma - epidemiology, Meningioma - genetics, Neurology, Neurosurgery, Physiological aspects, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Principal components analysis, Recruitment, Risk, Risk factors, Transcription Factors - genetics, Tumors of the nervous system. Phacomatoses