Nature genetics, 2009-06, Vol.41 (6), p.703-707
2009
Details
- Autor(en) / Beteiligte
- Titel
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
- Ist Teil von
- Nature genetics, 2009-06, Vol.41 (6), p.703-707
- Ort / Verlag
- New York, NY: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036, 1546-1718eISSN: 1546-1718DOI: 10.1038/ng.381Titel-ID: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_118831967
- Format
- –
- Schlagworte
- Algorithms, Antigens, CD - genetics, Biological and medical sciences, Chromosome Mapping - methods, Chromosomes, Human, Pair 1 - genetics, Chromosomes, Human, Pair 17 - genetics, Chromosomes, Human, Pair 2 - genetics, Colleges & universities, CTLA-4 Antigen, DEAD-box RNA Helicases - genetics, Diabetes, Diabetes Mellitus, Type 1 - epidemiology, Diabetes Mellitus, Type 1 - genetics, Diabetes Mellitus, Type 1 - immunology, Diabetes. Impaired glucose tolerance, DNA - genetics, Endocrine pancreas. Apud cells (diseases), Endocrinopathies, Etiopathogenesis. Screening. Investigations. Target tissue resistance, Family, Female, Fundamental and applied biological sciences. Psychology, Genetic aspects, Genetic testing, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Genomics, Genotype, HLA Antigens - genetics, Humans, Interferon-Induced Helicase, IFIH1, Male, Medical sciences, Medicin och hälsovetenskap, Mental health, Meta-analysis, Meta-Analysis as Topic, Polymorphism, Single Nucleotide - genetics, Principal components analysis, Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics, Quality control, Risk Assessment, Risk factors, Siblings, Single nucleotide polymorphisms, Studies, Type 1 diabetes