Details

Autor(en) / Beteiligte

• Burn, John
• Bishop, D. Timothy
• Mecklin, Jukka-Pekka
• Macrae, Finlay
• Möslein, Gabriela
• Olschwang, Sylviane
• Bisgaard, Marie-Luise
• Ramesar, Raj
• Eccles, Diana
• Maher, Eamonn R
• Bertario, Lucio
• Jarvinen, Heikki J
• Lindblom, Annika
• Evans, D. Gareth
• Lubinski, Jan
• Morrison, Patrick J
• Ho, Judy W.C
• Vasen, Hans F.A
• Side, Lucy
• Thomas, Huw J.W
• Scott, Rodney J
• Dunlop, Malcolm
• Barker, Gail
• Elliott, Faye
• Jass, Jeremy R
• Fodde, Ricardo
• Lynch, Henry T
• Mathers, John C

Titel

Effect of Aspirin or Resistant Starch on Colorectal Neoplasia in the Lynch Syndrome

Ist Teil von

• The New England journal of medicine, 2008-12, Vol.359 (24), p.2567-2578

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• This trial tested the influence of aspirin or resistant starch on the incidence of colorectal cancer or colonic adenomas in patients with the Lynch syndrome (hereditary nonpolyposis colon cancer). Neither intervention influenced the incidence of colorectal neoplasms in the Lynch syndrome. Neither aspirin or resistant starch influenced the incidence of colorectal neoplasms in the Lynch syndrome. The regular use of aspirin or aspirin-like agents is associated with a moderate reduction in the risk of colonic polyps and colorectal cancer. 1 – 4 Randomized trials of high-fiber diets have not shown a reduction in the risk of adenomas or colorectal cancer, 5 but none have investigated the effects of resistant starch. There is epidemiologic evidence of a negative correlation between colon cancer and starch intake. 6 Resistant starches escape digestion in the upper gut; colonic fermentation yields short-chain fatty acids, including butyrate, which has antineoplastic properties. 7 In carcinogen-treated rats, resistant starch reduces the development of intestinal tumors 8 , 9 and the production . . .