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Human Papillomavirus 16, 18, and 33 Infections and Risk of Prostate Cancer: A Nordic Nested Case-Control Study
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2005-12, Vol.14 (12), p.2952-2955
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2005
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Epidemiologic evidence of sexual history has emerged as a consistently found risk factor for prostate cancer. Some studies
have reported an association between human papillomavirus (HPV) infections and prostate cancer. We did a nested case-control
study within cohorts of more than 200,000 men enrolled in three Nordic biobanking projects. Follow-up using cancer registry
linkages identified 804 prospectively occurring prostate cancer cases. Four control subjects per case were randomly selected
from eligible sets of matched subjects that were alive and free of cancer at the time of diagnosis of the corresponding case
and were matched to cases on biobank cohort, age (±2 years), county of residence, and date of blood sampling (±2 months in
the Finnish and Swedish cohorts, ±6 months in the Norwegian cohort). The serum samples were analyzed by standard ELISAs for
the presence of immunoglobulin G antibodies against HPV types 16, 18, and 33. The joint HPV-16/HPV-18/HPV-33 seroprevalence
in the joint cohort was 13.4% (107 of 799) among cases and 14.0% (363 of 2,596) among controls (odds ratio, 0.94; 95% confidence
interval, 0.74-1.19). There were no noteworthy differences when the data were analyzed by different HPV type, country, or
antibody levels. Our data do not support an association between serologic markers of HPV-16, HPV-18, and HPV-33 infections
and risk of prostate cancer. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2952–5)