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The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Diabetes/metabolism research and reviews, 2010-05, Vol.26 (4), p.280-286
Abdul-Ghani, Muhammad A.
Lyssenko, Valeriya
Tuomi, Tiinamaija
DeFronzo, Ralph A.
Groop, Leif
2010
Details
Autor(en) / Beteiligte
Abdul-Ghani, Muhammad A.
Lyssenko, Valeriya
Tuomi, Tiinamaija
DeFronzo, Ralph A.
Groop, Leif
Titel
The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Ist Teil von
Diabetes/metabolism research and reviews, 2010-05, Vol.26 (4), p.280-286
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non‐diabetic subjects from the Botnia study received an OGTT at baseline and after 7–8 years of follow‐up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post‐load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1‐h compared to 2‐h during OGTT had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. Conclusions These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright © 2010 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1520-7552
eISSN: 1520-7560
DOI: 10.1002/dmrr.1084
Titel-ID: cdi_swepub_primary_oai_lup_lub_lu_se_ff5f9428_b66b_4a7c_a7d8_a7e6608ce782
Format
–
Schlagworte
Age Factors
,
Biological and medical sciences
,
Blood Glucose - metabolism
,
Blood Pressure - genetics
,
Body Mass Index
,
Body Weight - genetics
,
Cholesterol - blood
,
Cholesterol - genetics
,
Cholesterol, HDL - blood
,
Cholesterol, HDL - genetics
,
Clinical Medicine
,
Diabetes Mellitus, Type 2 - epidemiology
,
Diabetes. Impaired glucose tolerance
,
Endocrine pancreas. Apud cells (diseases)
,
Endocrinology and Diabetes
,
Endocrinopathies
,
Endokrinologi och diabetes
,
Etiopathogenesis. Screening. Investigations. Target tissue resistance
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Glucose Tolerance Test
,
Humans
,
Insulin - blood
,
Insulin - genetics
,
Klinisk medicin
,
Male
,
Medical and Health Sciences
,
Medical sciences
,
Medicin och hälsovetenskap
,
OGTT
,
prediction of diabetes
,
Risk Assessment
,
shape of glucose tolerance curve
,
Triglycerides - blood
,
Triglycerides - genetics
,
Vertebrates: endocrinology
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