Details

Autor(en) / Beteiligte

• Stitziel, Nathan O
• Stirrups, Kathleen E
• Masca, Nicholas G D
• Erdmann, Jeanette
• Ferrario, Paola G
• Webb, Thomas R
• Schick, Ursula M
• Lu, Yingchang
• Zhang, He
• Dube, Marie-Pierre
• Goel, Anuj
• Peloso, Gina M
• Won, Hong-Hee
• Do, Ron
• van Iperen, Erik
• Kanoni, Stavroula
• Mahajan, Anubha
• Scott, Robert A
• Willenberg, Christina
• van Capelleveen, Julian C
• Doney, Alex S F
• Asselta, Rosanna
• Merlini, Piera A
• Duga, Stefano
• Marziliano, Nicola
• Denny, Josh C
• Shaffer, Christian M
• Heilmann, Stefanie
• Hengstenberg, Christian
• Hoffman, Per
• Jansson, Jan-Håkan
• Jöckel, Karl-Heinz
• Kessler, Thorsten
• Kriebel, Jennifer
• Laugwitz, Karl L
• Marouli, Eirini
• Martinelli, Nicola
• Van Zuydam, Natalie R
• Meisinger, Christa
• Esko, Tõnu
• Mihailov, Evelin
• Escher, Stefan A
• Alver, Maris
• Moebus, Susanne
• Morris, Andrew D
• Müller-Nurasyid, Martina
• Olivieri, Oliviero
• Lemieux Perreault, Louis-Philippe
• AlQarawi, Alaa
• Robertson, Neil R
• Akinsanya, Karen O
• Reilly, Dermot F
• Vogt, Thomas F
• Yin, Wu
• Asselbergs, Folkert W
• Kooperberg, Charles
• Jackson, Rebecca D
• Stahl, Eli
• Waldenberger, Melanie
• Zeng, Lingyao
• Kraja, Aldi T
• Liu, Chunyu
• Ehret, George B
• Newton-Cheh, Christopher
• Chowdhury, Rajiv
• Ford, Ian
• Jukema, J Wouter
• Kee, Frank
• Nordestgaard, Børge G
• Sattar, Naveed
• Surendran, Praveen
• Tregouet, David
• Young, Robin
• Howson, Joanna M M
• Butterworth, Adam S
• Danesh, John
• Bottinger, Erwin P
• Erbel, Raimund
• Franks, Paul W
• Girelli, Domenico
• Hall, Alistair S
• Hovingh, G Kees
• Kastrati, Adnan
• Lieb, Wolfgang
• Meitinger, Thomas
• Kraus, William E
• McPherson, Ruth
• Orho-Melander, Marju
• Metspalu, Andres
• Palmer, Colin N A
• Rader, Daniel
• Loos, Ruth J F
• Tardif, Jean-Claude
• Wareham, Nicholas J
• Watkins, Hugh
• Willer, Cristen J
• Kathiresan, Sekkar
• Deloukas, Panos
• Samani, Nilesh J
• Schunkert, Heribert

Titel

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

Ist Teil von

• The New England journal of medicine, 2016-03, Vol.374 (12), p.1134-1144

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Searching for genes in which loss-of-function mutations confer protection against disease is a strategy to identity drug targets. This study reports an association between loss-of-function mutations in ANGPTL4 and protection against coronary artery disease. Although genomewide association studies have identified more than 56 loci associated with the risk of coronary artery disease, 1 – 3 the disease-associated variants are typically common (minor-allele frequency >5%) and located in noncoding sequences; this has made it difficult to pinpoint causal genes and affected pathways. This lack of a causal mechanism has in part hindered the immediate translation of the findings of genomewide association studies into new therapeutic targets. However, the discovery of rare or low-frequency coding-sequence variants that affect the risk of coronary artery disease has facilitated advances in the prevention and treatment of disease. The most recent example . . .