Details

Autor(en) / Beteiligte

• Bergholdt, Regine
• Størling, Zenia M
• Lage, Kasper
• Karlberg, E Olof
• Olason, Páll I
• Aalund, Mogens
• Nerup, Jørn
• Brunak, Søren
• Workman, Christopher T
• Pociot, Flemming

Titel

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

Ist Teil von

• Genome Biology, 2007-01, Vol.8 (11), p.R253-R253

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2007

Quelle

SpringerLink

Beschreibungen/Notizen

• We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.