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Variants in MTNR1B influence fasting glucose levels
Nature genetics, 2009-01, Vol.41 (1), p.77-81
2009

Details

Autor(en) / Beteiligte
Titel
Variants in MTNR1B influence fasting glucose levels
Ist Teil von
  • Nature genetics, 2009-01, Vol.41 (1), p.77-81
Ort / Verlag
New York, NY: Nature Publishing Group
Erscheinungsjahr
2009
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10−50) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 × 10−15). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 × 10−7) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 × 10−57) and GCK (rs4607517, P = 1.0 × 10−25) loci.
Sprache
Englisch
Identifikatoren
ISSN: 1061-4036, 1546-1718
eISSN: 1546-1718
DOI: 10.1038/ng.290
Titel-ID: cdi_swepub_primary_oai_lup_lub_lu_se_99652da4_3dd8_4107_adfe_b3a1f6f5d607
Format
–
Schlagworte
Allmän medicin, Biological and medical sciences, Biomedical research, Blood Glucose - genetics, Case-Control Studies, Clinical Medicine, Data analysis, Diabetes, Diabetes Mellitus, Type 2 - blood, Diabetes Mellitus, Type 2 - genetics, Diabetes Mellitus, Type 2 - physiopathology, Endocrinology and Diabetes, Endokrinologi och diabetes, Family Medicine, Fasting - blood, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Fundamental and applied biological sciences. Psychology, Genetic Predisposition to Disease, Genetics, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Glucose, Health Sciences, Health services, Humans, Hälsovetenskap, Klinisk medicin, Medical and Health Sciences, Medicin och hälsovetenskap, Meta-analysis, Meta-Analysis as Topic, Polymorphism, Single Nucleotide - genetics, Public Health, Global Health, Social Medicine and Epidemiology, Quantitative Trait Loci - genetics, Receptor, Melatonin, MT2 - genetics, Receptors, Melatonin - genetics, Sample size, Studies

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