Details

Autor(en) / Beteiligte

• Kapur, Rick
• Kim, Michael
• Aslam, Rukhsana
• McVey, Mark J.
• Tabuchi, Arata
• Luo, Alice
• Liu, Jonathan
• Li, Yuan
• Shanmugabhavananthan, Shanjeevan
• Speck, Edwin R.
• Zufferey, Anne
• Yousef, George
• Zhang, Haibo
• Rondina, Matthew T.
• Weyrich, Andrew S.
• Porcelijn, Leendert
• Kuebler, Wolfgang M.
• Slutsky, Arthur S.
• Semple, John W.

Titel

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Ist Teil von

• Blood, 2017-05, Vol.129 (18), p.2557-2569

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti–major histocompatibility complex class I antibodies, we found CD4+CD25+FoxP3+ T regulatory cells (Tregs) and CD11c+ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion. •CD4+CD25+FoxP3+ T regulatory cells and CD11c+ dendritic cells protect against antibody-mediated murine TRALI.•Murine TRALI is associated with reduced IL-10 levels, and IL-10 administration prevents and rescues TRALI development.