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Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer
The Prostate, 2005-06, Vol.64 (1), p.29-39
Bjartell, Anders
Paju, Annukka
Zhang, Wan-Ming
Gadaleanu, Virgil
Hansson, Jens
Landberg, Göran
Stenman, Ulf-Håkan
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Bjartell, Anders
Paju, Annukka
Zhang, Wan-Ming
Gadaleanu, Virgil
Hansson, Jens
Landberg, Göran
Stenman, Ulf-Håkan
Titel
Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer
Ist Teil von
The Prostate, 2005-06, Vol.64 (1), p.29-39
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
Wiley Online Library Database Model
Beschreibungen/Notizen
BACKGROUND Trypsinogens are pancreatic serine proteinases and expressed in several cancers as tumor‐associated trypsinogens (TAT). Trypsin mediates activation of pro‐uPA and pro‐MMPs, thus promoting angiogenesis and tumor invasion. Recently, we described expression of TAT in the human male genital tract and now we studied TAT in relation to PSA in PCa. METHODS TAT expression was studied by immunohistochemistry, in situ hybridization, RT‐PCR, DNA‐sequencing and IFMA. LNCaP cells were used to study secretion of TAT and PSA after androgen stimulation. RESULTS Immunoreactive TAT was localized in all prostatic tumors (n = 109), lymph node (n = 16), and bone metastases (n = 17). Immunostaining intensity increased with higher Gleason's grade, whereas PSA immunostaining decreased significantly. PSA and TAT were not identically distributed in benign and malignant cells. Androgen stimulation of LNCaP cells decreased secretion of TAT and increased that of PSA. TAT mRNA was demonstrated in tissue sections and identified as TAT‐1 and ‐2 by RT‐PCR and DNA‐sequencing. CONCLUSIONS Expression of TAT is better preserved than PSA in high‐grade PCa. Expression of TAT and PSA is regulated by different mechanisms as demonstrated in tissue sections and in vitro. Locally produced TAT may act in a paracrine mode to promote angiogenesis and tumor invasion in PCa by both activating and degrading of other proteinases. Further studies on the role of TAT in invasive PCa and on the mechanisms involved in the regulation of TAT expression are warranted. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0270-4137
eISSN: 1097-0045
DOI: 10.1002/pros.20236
Titel-ID: cdi_swepub_primary_oai_lup_lub_lu_se_6933f343_bf0d_4450_a13e_73b222aef9d4
Format
–
Schlagworte
Biological and medical sciences
,
Clinical Medicine
,
Gene Expression Regulation, Enzymologic
,
Gene Expression Regulation, Neoplastic
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Immunohistochemistry
,
In Situ Hybridization
,
In Vitro Techniques
,
kallikreins
,
Klinisk medicin
,
Male
,
Male genital diseases
,
Medical and Health Sciences
,
Medical sciences
,
Medicin och hälsovetenskap
,
Metribolone - pharmacology
,
Nephrology. Urinary tract diseases
,
Obstetrics, Gynecology and Reproductive Medicine
,
Oligonucleotide Array Sequence Analysis
,
Paracrine Communication
,
Prostate-Specific Antigen - genetics
,
Prostate-Specific Antigen - metabolism
,
Prostatic Neoplasms - metabolism
,
Prostatic Neoplasms - pathology
,
Prostatic Neoplasms - physiopathology
,
proteases
,
Reproduktionsmedicin och gynekologi
,
RT-PCR
,
Trypsin - genetics
,
Trypsin - metabolism
,
Trypsinogen - genetics
,
Trypsinogen - metabolism
,
Tumors
,
Tumors of the urinary system
,
Urinary tract. Prostate gland
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