Details

Autor(en) / Beteiligte

• Aunes-Jansson, Maria, MD
• Edvardsson, Nils, MD, PhD
• Stridh, Martin, PhD
• Sörnmo, Leif, PhD
• Frison, Lars, PhD
• Berggren, Anders, MD, PhD

Titel

Decrease of the atrial fibrillatory rate, increased organization of the atrial rhythm and termination of atrial fibrillation by AZD7009

Ist Teil von

• Journal of electrocardiology, 2013, Vol.46 (1), p.29-35

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background The atrial fibrillatory rate (AFR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development. Methods Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST cancellation the AFR, its standard deviation (SD), the exponential decay and the atrial electrogram amplitude were determined as 3-min averages. Results The mean AFR rapidly decreased by 43% from baseline (394 ± 38 to 225 ± 61 fibrillations/min, p = 0.0003) on AZD7009, but not on placebo. The SD of the AFR and the exponential decay decreased in parallel. In 2 of 8 patients, termination of AF occurred after the AFR had decreased by 58% and 53%, respectively. Conclusions The AFR may potentially serve as a biomarker of electrophysiological effects in early evaluation of rhythm control agents.