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Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
Movement disorders, 2010-06, Vol.25 (8), p.1091-1096
Li, Jia-Yi
Englund, Elisabet
Widner, Håkan
Rehncrona, Stig
Björklund, Anders
Lindvall, Olle
Brundin, Patrik
2010
Details
Autor(en) / Beteiligte
Li, Jia-Yi
Englund, Elisabet
Widner, Håkan
Rehncrona, Stig
Björklund, Anders
Lindvall, Olle
Brundin, Patrik
Titel
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
Ist Teil von
Movement disorders, 2010-06, Vol.25 (8), p.1091-1096
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease. Here, we have used immunohistochemistry and electron microscopy to characterize the development of Lewy bodies in one of these cases. This patient was operated in putamen on both sides at 12 or 16 years before death, respectively. We demonstrate that 2% of the 12‐year‐old and 5% of the 16‐year‐old grafted, presumed dopaminergic neurons contained Lewy bodies immunoreactive for α‐synuclein. Based on morphological analysis, two forms of α‐synuclein‐positive aggregates were distinguished in the grafts, the first a classical and compact Lewy body, the other a loose meshwork aggregate. Lewy bodies in the grafts stained positively for ubiquitin and thioflavin‐S, and contained characteristic α‐synuclein immunoreactive electron dense fibrillar structures on electron microscopy. Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra. © 2010 Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.23012
Titel-ID: cdi_swepub_primary_oai_lup_lub_lu_se_40867eef_c7f9_449b_8e0e_5a0a56c75550
Format
–
Schlagworte
alpha-synuclein
,
alpha-Synuclein - metabolism
,
Biological and medical sciences
,
Clinical Medicine
,
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
,
Fetal Tissue Transplantation - methods
,
Humans
,
Klinisk medicin
,
Lewy Bodies - metabolism
,
Lewy Bodies - pathology
,
Lewy Bodies - ultrastructure
,
Lewy body
,
Longitudinal Studies
,
Male
,
Medical and Health Sciences
,
Medical sciences
,
Medicin och hälsovetenskap
,
Mesencephalon - cytology
,
Microscopy, Electron, Transmission - methods
,
Middle Aged
,
neural transplantation
,
Neurologi
,
Neurology
,
Neurons - metabolism
,
Neurons - pathology
,
Neurons - ultrastructure
,
Parkinson Disease - pathology
,
Parkinson Disease - surgery
,
Postmortem Changes
,
protein aggregation
,
Thiazoles
,
Time Factors
,
transmissible neurological disease
,
α-synuclein
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