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Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model
British journal of surgery, 2001-02, Vol.88 (2), p.228-234
Syk, I.
Ågren, M. S.
Adawi, D.
Jeppsson, B.
2001
Details
Autor(en) / Beteiligte
Syk, I.
Ågren, M. S.
Adawi, D.
Jeppsson, B.
Titel
Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model
Ist Teil von
British journal of surgery, 2001-02, Vol.88 (2), p.228-234
Ort / Verlag
Oxford, UK: Blackwell Science Ltd
Erscheinungsjahr
2001
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Background: The breaking strength of colonic anastomoses declines after operation to a minimum at days 3–4, with a subsequent risk of anastomotic dehiscence. The mechanism is thought to be collagen degradation by matrix metalloproteinases (MMPs). This study examined the pathogenic role of MMPs on the mechanical strength of colonic anastomoses by giving the synthetic broad‐spectrum MMP inhibitor BB‐1101 systemically. Methods: Forty‐eight male Sprague–Dawley rats were treated daily for 7 days with BB‐1101 30 mg/kg or vehicle alone (control) starting 2 days before operation. The breaking strength of standardized left‐sided colonic anastomoses was measured on postoperative days 1, 3 and 7. Results: Serum BB‐1101 levels were increased at 100 nmol/l in BB‐1101‐treated rats. The anastomotic breaking strength was 48 per cent higher (P = 0·02) in BB‐1101‐treated animals compared with controls on postoperative day 3. Neither collagen accumulation nor infiltration of neutrophils in the anastomotic area was influenced by BB‐1101 treatment. Net deposition of new collagen in subcutaneous sponges was unaffected by the BB‐1101. Conclusion: The enhanced breaking strength of colonic anastomoses during the critical early postoperative phase found after administration of a broad‐spectrum MMP inhibitor implies that MMPs might increase the risk of anastomotic dehiscence. Presented in part to the third joint meeting of the European Tissue Repair Society and the Wound Healing Society in Bordeaux, France, 24–28 August 1999, and published in form in Wound Repair Regen 1999; 7: A321 © 2001 British Journal of Surgery Society Ltd
Sprache
Englisch
Identifikatoren
ISSN: 0007-1323, 1365-2168
eISSN: 1365-2168
DOI: 10.1046/j.1365-2168.2001.01649.x
Titel-ID: cdi_swepub_primary_oai_lup_lub_lu_se_293d237e_4356_4b3f_ab04_e1eed359f996
Format
–
Schlagworte
Anastomosis, Surgical
,
Animals
,
Benzyl Compounds
,
Biological and medical sciences
,
Clinical Medicine
,
Collagen - metabolism
,
Colon - surgery
,
Dexamethasone - blood
,
Dexamethasone - therapeutic use
,
Drug Combinations
,
Hydroxyproline - metabolism
,
Kirurgi
,
Klinisk medicin
,
Male
,
Matrix Metalloproteinase Inhibitors
,
Medical and Health Sciences
,
Medical sciences
,
Medicin och hälsovetenskap
,
Pentoxifylline - blood
,
Pentoxifylline - therapeutic use
,
Protease Inhibitors - therapeutic use
,
Rats
,
Rats, Sprague-Dawley
,
Stomach, duodenum, intestine, rectum, anus
,
Succinates
,
Surgery
,
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
,
Surgery of the digestive system
,
Surgical Wound Dehiscence - physiopathology
,
Surgical Wound Dehiscence - prevention & control
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