Details

Autor(en) / Beteiligte

• Sánchez-Benavides, Gonzalo
• Suárez-Calvet, Marc
• Milà-Alomà, Marta
• Arenaza-Urquijo, Eider M.
• Grau-Rivera, Oriol
• Operto, Grégory
• Gispert, Juan Domingo
• Vilor-Tejedor, Natalia
• Sala-Vila, Aleix
• Crous-Bou, Marta
• González-de-Echávarri, José Maria
• Minguillon, Carolina
• Fauria, Karine
• Simon, Maryline
• Kollmorgen, Gwendlyn
• Zetterberg, Henrik
• Blennow, Kaj
• Molinuevo, José Luis

Titel

Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume

Ist Teil von

• Neurobiology of aging, 2021-08, Vol.104, p.24-31

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• •Neurofilament light in cerebrospinal fluid is increased in subjective cognitive decline.•This association is driven by individuals harboring amyloid-beta pathology.•When amyloid pathology and subjective cognitive decline concur there is a negative association between neurofilament levels and hippocampal volume.•These associations are independent of age, gender, mood and cardiovascular risk. Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective Cognitive Decline (SCD) and hippocampal volume, and how CSF amyloid-β (Aβ) modifies these associations. We included 278 cognitively unimpaired participants from the Alfa+ cohort (78 SCD and 200 Controls). Linear models accounting for covariates (age, gender, and mood) were used to test the association between CSF NfL and SCD status, and between CSF NfL and bilateral hippocampal volumes. Interactions with Aβ were also explored. Individuals with SCD had higher CSF NfL and lower CSF Aβ42/40 than Controls. There was a significant interaction between SCD and CSF-Aβ42/40 levels. Stratified analyses showed a significant association between SCD and NfL only in Aβ+ individuals. Higher CSF NfL was significantly associated with lower hippocampal volume specifically in Aβ+ individuals with SCD. The presence of SCD in Aβ+ individuals may represent an early symptom in the Alzheimer's continuum related to incipient neurodegeneration. [Display omitted]