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Cognitive impairment in Glucocerebrosidase (GBA)‐associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles
Movement disorders, 2017-12, Vol.32 (12), p.1780-1783
Lerche, Stefanie
Schulte, Claudia
Srulijes, Karin
Pilotto, Andrea
Rattay, Tim W.
Hauser, Ann‐Kathrin
Stransky, Elke
Deuschle, Christian
Csoti, Ilona
Lachmann, Ingolf
Zetterberg, Henrik
Liepelt‐Scarfone, Inga
Gasser, Thomas
Maetzler, Walter
Berg, Daniela
Brockmann, Kathrin
2017
Details
Autor(en) / Beteiligte
Lerche, Stefanie
Schulte, Claudia
Srulijes, Karin
Pilotto, Andrea
Rattay, Tim W.
Hauser, Ann‐Kathrin
Stransky, Elke
Deuschle, Christian
Csoti, Ilona
Lachmann, Ingolf
Zetterberg, Henrik
Liepelt‐Scarfone, Inga
Gasser, Thomas
Maetzler, Walter
Berg, Daniela
Brockmann, Kathrin
Titel
Cognitive impairment in Glucocerebrosidase (GBA)‐associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles
Ist Teil von
Movement disorders, 2017-12, Vol.32 (12), p.1780-1783
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
ABSTRACT Background A proportion of idiopathic Parkinson's disease patients (PDidiopathic) with dementia show altered CSF profiles of amyloid β (Aβ) and Tau. PD patients with Glucocerebrosidase (GBA) mutations (PDGBA) present with even more cognitive decline than seen in PDidiopathic. Objective The objective of this study was to evaluate whether CSF profiles of Aβ and tau are associated with the prominent cognitive impairment in PDGBA. Methods CSF levels of Aβ1‐42, t‐Tau, p‐Tau, and total alpha‐synuclein were assessed in 479 participants (50 PDGBA, 308 PDidiopathic, 121 healthy controls). Results Older age was associated with cognitive impairment in PDGBA and PDidiopathic. Despite prominent cognitive impairment, PDGBA showed similar CSF levels of Aβ1‐42, t‐Tau, and p‐Tau as seen in healthy controls. In contrast, lower levels of Aβ1‐42 and higher levels of t‐Tau and p‐Tau were associated with worse cognitive performance in PDidiopathic. Conclusions The prominent cognitive impairment in PDGBA seems not primarily associated with Aβ and Tau profiles in CSF. © 2017 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185, 1531-8257
eISSN: 1531-8257
DOI: 10.1002/mds.27199
Titel-ID: cdi_swepub_primary_oai_gup_ub_gu_se_260510
Format
–
Schlagworte
Abeta
,
Adolescent
,
Adult
,
Aged
,
Aged, 80 and over
,
alpha‐synuclein
,
Amyloid beta-Peptides - cerebrospinal fluid
,
Cerebrospinal fluid
,
Cognition Disorders - etiology
,
Cognitive ability
,
CSF
,
Dementia disorders
,
Female
,
GBA
,
Glucosylceramidase
,
Glucosylceramidase - genetics
,
Humans
,
Male
,
Middle Aged
,
Movement disorders
,
Mutation - genetics
,
Neurodegenerative diseases
,
Neuropsychological Tests
,
Neurosciences
,
Neurovetenskaper
,
Parkinson
,
Parkinson Disease - cerebrospinal fluid
,
Parkinson Disease - complications
,
Parkinson Disease - genetics
,
Parkinson's disease
,
Peptide Fragments - cerebrospinal fluid
,
Retrospective Studies
,
Severity of Illness Index
,
Statistics, Nonparametric
,
Synuclein
,
Tau
,
tau Proteins - cerebrospinal fluid
,
Young Adult
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