Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...

Details

Autor(en) / Beteiligte
Titel
Association between low C-peptide and fragility fractures in postmenopausal women without diabetes
Ist Teil von
  • Journal of endocrinological investigation, 2017-10, Vol.40 (10), p.1091-1098
Ort / Verlag
Cham: Springer International Publishing
Erscheinungsjahr
2017
Quelle
MEDLINE
Beschreibungen/Notizen
  • Purpose C-peptide has been shown to exert several, previously unknown, biological effects. A recent cross-sectional study demonstrated an association between low C-peptide serum levels and low lumbar bone density of postmenopausal women not affected by diabetes. To date, very little research attention has been directed toward the association between C-peptide and osteoporotic fractures. To contribute toward filling this gap, we investigated the association between C-peptide and fractures in postmenopausal women. Methods A cohort of 133 non-diabetic postmenopausal women with and without a history of fractures was evaluated in this cross-sectional investigation. Standardized interviews were performed to gather information on the patients’ fracture history. All of the participants underwent a bone mineral density assessment by DXA, radiographs, and a serum C-peptide measurement. Results Thirty-four women presented fractures. Bivariate analysis revealed an inverse correlation between C-peptide and fractures ( r  = −0.27, p  = 0.002). A significant difference in mean C-peptide levels was also found between women with vs. without fractures ( p  = 0.01, adjusted for age, BMI and glucose). Logistic regression analysis showed that C-peptide levels, femoral and vertebral BMD were all negatively associated with fracture status ( B  = −1.097, ES = 0.401, p  = 0.006, 95% CI 0.15–0.73; B  = −15.6, SE = 4.17, p  < 0.001, CI 0.001–0.002; B  = −24.8, SE = 5.23, p  < 0.001, CI 0001–0.002; respectively). Conclusions This study confirms an inverse association between serum C-peptide levels and a history of fractures in postmenopausal women without diabetes. These results suggest that C-peptidemay exert an effect on bone mineral density. However, further large-scale studies are needed to corroborate this finding and investigate the potential underlying mechanisms involved.

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX